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To explore the neural and cognitive mechanisms of depression (including unipolar depression and Bipolar disorder) and anxiety using multimodal MRI techniques.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| healthy control | Well mathed with patients in age, gender, education | ||
| major depression disorder | patients with major depression disorder | ||
| anxiety disorder | patients with anxiety disorder | ||
| bipolar depression disorder | patients with bilopar depression disorder |
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| Measure | Description | Time Frame |
|---|---|---|
| Brain structural and functional changes in patients | Structure and function changes in patients will be assessed by Voxel-based morphometry analysis for structural changes, as well as Regional homogeneity, Amplitude of lowfrequency fluctuation, etc, for functional changes. | one time point |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with major depression, bilopar, anxiety disorders were recruited from the mental health center of Chengdu, Sichuan, China.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Huafu Chen | Contact | chenhf@uestc.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| School of Life Science and Technology, University of Electronic Science and Technology | Recruiting | Chengdu | Sichuan | 610054 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34111495 | Derived | Chen Y, Cui Q, Sheng W, Tang Q, Lu F, Pang Y, Nan X, He Z, Li D, Lei T, Chen H. Anomalous neurovascular coupling in patients with generalized anxiety disorder evaluated by combining cerebral blood flow and functional connectivity strength. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110379. doi: 10.1016/j.pnpbp.2021.110379. Epub 2021 Jun 7. | |
| 32621959 |
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| ID | Term |
|---|---|
| D003863 | Depression |
| D001008 | Anxiety Disorders |
| D001714 | Bipolar Disorder |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D001523 | Mental Disorders |
| D000068105 | Bipolar and Related Disorders |
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| Yang Y, Cui Q, Pang Y, Chen Y, Tang Q, Guo X, Han S, Ameen Fateh A, Lu F, He Z, Huang J, Xie A, Li D, Lei T, Wang Y, Chen H. Frequency-specific alteration of functional connectivity density in bipolar disorder depression. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jan 10;104:110026. doi: 10.1016/j.pnpbp.2020.110026. Epub 2020 Jul 2. |
| 30597300 | Derived | Wang Y, Wang X, Ye L, Yang Q, Cui Q, He Z, Li L, Yang X, Zou Q, Yang P, Liu D, Chen H. Spatial complexity of brain signal is altered in patients with generalized anxiety disorder. J Affect Disord. 2019 Mar 1;246:387-393. doi: 10.1016/j.jad.2018.12.107. Epub 2018 Dec 26. |
| D019964 |
| Mood Disorders |