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The aim of our prospective multicenter study was to investigate the prognostic value of the acute and long-term changes of liver stiffness in patients receiving a transjugular intrahepatic portosystemic shunt (TIPS).
We included 83 patients receiving TIPS for prevention of rebleeding, therapy-refractory ascites or both. Hemodynamic parameters were assessed before TIPS and after TIPS insertion. 16 patients from Freiburg underwent TE immediately before and after TIPS. In 67 patients from Bonn, SWE of liver and spleen, as well as clinical and biochemical parameters were assessed before TIPS, seven days and six weeks after TIPS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | receiving TE before and 30 min after TIPS |
| |
| 2 | receiving SWE before and 7 days, 6 weeks and 3 months after TIPS |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stiffness measurement | Diagnostic Test | Transient Elastopgraphy (TE) or Shear-Wave-Elastography |
|
| Measure | Description | Time Frame |
|---|---|---|
| Survival | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Acute-on-chronic Lvier failure | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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This prospective multicentre study included patients, which underwent TIPS insertion and had reliable SWE or TE measurement of the liver before TIPS.
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29059466 | Derived | Jansen C, Moller P, Meyer C, Kolbe CC, Bogs C, Pohlmann A, Schierwagen R, Praktiknjo M, Abdullah Z, Lehmann J, Thomas D, Strassburg CP, Latz E, Mueller S, Rossle M, Trebicka J. Increase in liver stiffness after transjugular intrahepatic portosystemic shunt is associated with inflammation and predicts mortality. Hepatology. 2018 Apr;67(4):1472-1484. doi: 10.1002/hep.29612. Epub 2018 Feb 20. |
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| ID | Term |
|---|---|
| D006975 | Hypertension, Portal |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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Plasma and serum samples