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| Name | Class |
|---|---|
| First Affiliated Hospital of Wenzhou Medical University | OTHER |
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Percutaneous microwave ablation(MWA) was reported as an effective modality for the management of thyroid nodules(TNs). This study aims to validate MWA as a feasible approach for patients with TNs for whom surgery is contraindicated or refused. Two groups of subjects with TNs(one group to treat with MWA and the other group to receive regular ultrasonic follow-up without any treatment) will be evaluated in term of TN volume, ultrasonic image and clinical symptoms.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Experimental | MWA Percutaneous Microwave Ablation intervention procedure: Ultrasound-guided Percutaneous Microwave Ablation |
|
| Group B | No Intervention | untreated no treatment; regular ultrasonic image follow-up |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Microwave Ablation | Device | Ultrasound-guided Percutaneous Microwave Ablation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of the thyroid nodule volume assessed by ultrasonography after treatment vs simple clinical observation | Change of the thyroid nodule volume assessed by using ultrasonography, the volume reduction ratio(VRR) was calculated by the equation: VRR%=[(initial volume-final volume)*100]/initial volume | From time to treatment until 12 months. Time point evaluations at 1,3,6,12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Improved score on TN-related symptoms | Evaluation of TN-related neck symptoms scored separately as follow:0(absent),1(moderate),2(severe). The sum of the individual scores generates a final score(SYS score) ranging from 0 to 6 | From time to treatment until 12 months. Time point evaluations at 1,3,6,12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zimiao Chen | Contact | 86-0577-88069715 | zimiaochen@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Xiaojun Chen | Thyroid Center of The First Affiliated Hospital of Wenzhou Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital of Wenzhou Medical University | Recruiting | Wenzhou | Zhejiang | 325000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29333159 | Derived | Wu W, Gong X, Zhou Q, Chen X, Chen X. Ultrasound-Guided Percutaneous Microwave Ablation for Solid Benign Thyroid Nodules: Comparison of MWA versus Control Group. Int J Endocrinol. 2017;2017:9724090. doi: 10.1155/2017/9724090. Epub 2017 Nov 23. |
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| ID | Term |
|---|---|
| D016606 | Thyroid Nodule |
| ID | Term |
|---|---|
| D013964 | Thyroid Neoplasms |
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| Improved cosmetic grading score |
Cosmetic problem evaluated by grading score(1,no palpable mass;2, no cosmetic problem but palpable mass; 3, a cosmetic problem on swallowing only; and 4, a readily detected cosmetic problem |
| From time to treatment until 12 months. Time point evaluations at 1,3,6,12 months |
| D006258 |
| Head and Neck Neoplasms |
| D004700 | Endocrine System Diseases |
| D013959 | Thyroid Diseases |