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| Name | Class |
|---|---|
| Canola Council of Canada | OTHER |
| University of Manitoba | OTHER |
| Laval University | OTHER |
| Unity Health Toronto |
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Building on the findings from the investigators previous study, COMIT I, the purpose of the COMIT II study is to supplement the DEXA measurement of body composition with a supplementary DEXA measurement of visceral adipose tissue and to specifically target the impact of oleic acid consumption on body composition as the primary objective. COMIT II also will include analysis of fatty acid ethanolamines (FAEs) and their precursors to elucidate the mechanisms by which canola oil may be modifying body composition, measurement of endothelial function, inflammatory, adiposity and insulin sensitivity biomarkers, and genetic analyses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Canola oil | Experimental | regular canola oil |
|
| High oleic acid canola oil | Experimental | high stability/high oleic canola oil |
|
| Western diet oil combination | Active Comparator | a typical "Western diet" fat intake comprised of 11% MUFA, 11% PUFA (9% omega-6 fatty acids and 2% omega-3 fatty acids), and 13% SFA |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Canola Oil | Other | Regular canola oil will be iso-calorically incorporated into fruit smoothies made with milk and consumed twice daily. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Body composition | Will be measured using DXA | 1 year 6 months |
| Plasma lipids | 1 year 6 months | |
| Flow mediated dilation (FMD) for endothelial function | 1 year 6 months | |
| Lipoprotein subclasses | 1 year 6 months | |
| Inflammatory markers | 1 year 6 months | |
| Lipid Peroxidation | 1 year 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of fatty acid inter-conversion and synthesis using stable isotope tracers | 1 year 6 months | |
| Genetic analysis to evaluate the association between FADS 1 and FADS 2 mRNA and protein expression in peripheral blood mononuclear blood cells (PBMCs) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Penny M Kris-Etherton, PhD | Penn State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Penn State University | University Park | Pennsylvania | 16802 | United States |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| D000074262 | Rapeseed Oil |
| ID | Term |
|---|---|
| D010938 | Plant Oils |
| D009821 | Oils |
| D008055 | Lipids |
| D028321 | Plant Preparations |
| D001688 |
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| OTHER |
| St. Boniface Hospital | OTHER |
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| High oleic acid canola oil | Other | High oleic acid canola oil will be iso-calorically incorporated into fruit smoothies made with milk and consumed twice daily. |
|
| Western diet oil combination | Other | A typical "Western diet" fat intake as a control treatment, comprised of 11% MUFA, 11% PUFA (9% omega-6 fatty acids and 2% omega-3 fatty acids), and 13% SFA, will be iso-calorically incorporated into fruit smoothies made with milk and consumed twice daily |
|
| 1 year 6 months |
| Physical activity level | Will be assessed using an Actigraph GT3X+ activity monitor to be worn for 1 week at the end of each treatment period | 1 year 6 months |
| D009750 |
| Nutritional and Metabolic Diseases |
| Biological Products |
| D045424 | Complex Mixtures |