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To Evaluate the effect of addition of Dexmedetomedine to ultrasound guided modified Pecs block on post operative analgesia & stress response in patient undergoing modified radical mastectomy.
60 patients (age ≥29 years) who scheduled for modified radical mastectomy surgery under general anesthesia. Group I (Bupivacaine group): patients underwent modified radical mastectomy were given preoperative ultrasound guided modified Pecs block with 30 mL of 0.25% bupivacaine divided into 10 ml injected between the pectoralis muscles on the interfasial plane, and 20 ml injected between the Pectoralis minor muscle and the serratus muscle.Group II (Bupivacaine + Dexmedetomidine group) : preoperative ultrasound guided modified Pecs block with 30 mL of 0.25% bupivacaine plus Dexmedetomidine (1 µg/kg) divided into 20 ml injected between the pectoralis muscles on the interfasial plane , and 10 ml injected between the Pectoralis minor muscle and the serratus muscle.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| dexmetedomedine | Active Comparator | preoperative ultrasound guided modified Pecs block with 30 mL of 0.25% bupivacaine plus Dexmedetomidine (1 µg/kg) |
|
| control | Placebo Comparator | preoperative ultrasound guided modified Pecs block with 30 mL of 0.25% bupivacaine |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug | preoperative ultrasound guided modified Pecs block with 30 mL of 0.25% bupivacaine plus Dexmedetomidine (1 µg/kg) |
|
| Measure | Description | Time Frame |
|---|---|---|
| morphine consumption mg/day | by Patient-controlled analgesia (PCA) device | 48 HOURS |
| Visual Analog Scale (VAS), scored from 0-10 | pain measurement | 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| first request of analgesia | time of the first request of analgesia postoperative if the VAS ≥ 3 | 48 hours |
| level of stress hormones | cortisol level |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| mohamad F mohamad, MD | Contact | +201093942354 | mfaroukma@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| mohamad F mohamad, MD | Assiut University | Principal Investigator |
| Saher mohamad, MD | Cancer Institute, Anesthesia, Intensive Care, and Pain Management, South Egypt Cancer Institute, Assiut University, Assiut, Egypt. |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| South Egypt Cancer Institute, Assiut University, Assiut, Egypt. | Recruiting | Asyut | 171516 | Egypt |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| placebo | Drug | preoperative ultrasound guided modified Pecs block with 30 mL of 0.25% bupivacaine |
|
|
| 48 hours |
| Adverse Events | Nausea Vomiting Bradycardia Hypotension Arrhythmia Pneumothorax Vascular injury Nausea Vomiting Bradycardia Hypotension Arrhythmia Pneumothorax Vascular injury Nausea,Vomiting,Arrhythmia.Hypotension,Pneumothorax,Vascular injury andItching | 48 hours |