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Chronic low back pain patients aged 21 to 60 needed for a research study of the effects of transcranial direct current stimulation (tDCS) on the analgesic effects of lidocaine cream as measured by functional Magnetic Resonance Imaging (fMRI). Study will be conducted on nine separate days not requiring an overnight stay in the hospital.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| real tDCS | Active Comparator | In this group, the tDCS stimulates areas of the brain being examined in this study to increase their activity. |
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| sham tDCS | Sham Comparator | In this group, sham tDCS does not provide real stimulation though participants will not know this until the debriefing at the end of the study. Sham will be used to determine if the results of this study are due to the tDCS or other reasons. |
|
| control group | Other | In this group, participants will receive tDCS but will only receive a cream on their lower back. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tDCS | Device | Electrical stimulation will be applied on the head to temporarily influence brain activity in specific regions. |
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| Measure | Description | Time Frame |
|---|---|---|
| fMRI signal changes | 2 days; Sessions 5 and 7 | |
| Gracely Scale pain rating changes | 2 days; Sessions 2 and 7 | |
| resting state functional connectivity changes | 2 days; Sessions 5 and 7 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Georgia Wilson, BA | Contact | 617-726-5004 | gjwilson@mgh.harvard.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Martinos Center for Biomedical Imagin | Recruiting | Charlestown | Massachusetts | 02129 | United States |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Jan 4, 2024 | |
| Reset | Jun 14, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jan 4, 2024 | Jun 14, 2024 |
| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| Lidocaine cream | Other | Lidocaine cream will be applied to reduce pain sensitivity (analgesia). |
|
| Control cream | Other | A neutral cream will be applied as a control. |
|
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |