The purpose of the study is to evaluate the efficacy and safety of prophylactic use of antibiotics in endoscopic injection of tissue adhesive in gastric varices.

Gastroesophageal variceal bleeding is the most common and life-threatening condition in patients with portal hypertension, which are susceptibility to bacterial infection. However, the prophylaxis use of antibiotics remained uncertain and lack of high level evidences.This study is a randomized controlled trial. The purpose of the study is to evaluate the efficacy and safety of prophylactic use of antibiotics in endoscopic injection of tissue adhesive in gastric varices.

Inclusion Criteria:

• 18 y.o. ≤age≤75 y.o.;
• Diagnosis of esophageal gastric varices by gastroscopy;
• Cirrhotic gastroesophageal variceal bleeding underwent endoscopic injection of tissue adhesive;

Exclusion Criteria:

• age <18 y.o. or age > 75 y.o.;
• Never had the variceal bleeding episode before;
• Do not have endoscopic injection of tissue adhesive;
• The cefotiam contraindications: such as allergies, pregnancy etc;
• combined with other malignant tumor (not exclude patients with hepatocellular carcinoma who don't not need treatment at the moment);
• Known infection before endoscopic treatment (Fever, microbial cultures positive, et al.);
• Massive ascites or combined with other high risk factor that require prophylaxis use of antibiotics;
• Acute variceal bleeding within 5 days;
• Refuse to participate