Comparison Between Low Dose and High Dose Intra-articular Tranexamic Acid in Total Knee Arthroplasty

Topical Intra-Articular High Doses Compared With Low Doses of Tranexamic Acid to Reduce Blood Loss in Primary Total Knee Arthroplasty: A Double-Blind Randomized Controlled Trial

The purpose of this study is to compare blood loss between using low dose (500 mg) and high dose (3 g) topical intra-articular tranexamic acid after total knee arthroplasty in double-blind RCT

Inclusion Criteria:

• Osteoarthritic knee who underwent primary total knee arthroplasty

Exclusion Criteria:

• Abnormal coagulation or bleeding disorder
• Allergy to tranexamic acid
• History of thromboembolism or ischemic heart disease or cerebrovascular accident
• chronic kidney disease stage 3-4