Safety of Different Forms of Creatine

Short-Term Safety and Dose Effects of Different Forms of Creatine

This study will aim to determine whether ingesting creatine nitrate (CrN) at higher doses will differentially affect hemodynamic variables compared to a placebo.

This study will examine the short-term (7 day) characteristics of ingesting creatine nitrate (CrN) compared to placebo on Chem-15 blood safety, heart rate, blood pressure, heart rate and blood pressure reactivity and self-reported side effects.

Inclusion Criteria:

• Apparently healthy
• At least 6 months immediate prior history of resistance training including bench press and leg press or squat

Exclusion Criteria:

• A history of treatment for metabolic disease (i.e., diabetes), hypertension, hypotension, thyroid disease, arrhythmias and/or cardiovascular disease
• Use of prescription medication (birth control is allowed)
• Pregnant or nursing or plan to become pregnant during the next month
• Creatine or nitrate use in the last eight weeks
• History of smoking
• History of drinking (i.e., 12 drinks per week or more)
• Use of nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, Nuprin, etc.), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene)