Investigation of Exercise Training-Induced Myokines and Adipolkines in Humans

Investigation of Exercise Training-Induced Myokines and Adipolkines in Humans

The purpose of this study is to find out whether exercise training leads to changes in the blood that are produced by exercised muscles and if these changes produce new hormones that affect the body's regulation of sugar and body weight.

Inclusion Criteria:

- Age between 18-35. Body mass index (BMI) must be ≥18.5 and ≤27 kg/m2. HbA1c values ≤5.7%

Exclusion Criteria:

• Age <18 and >50
• HbA1c ≥ 5.7%; heart or lung disease
• acute systemic infection accompanied by fever, body aches, or swollen lymph glands
• BMI > 27 kg/m2
• current dieting or weight loss efforts
• current pregnancy or breastfeeding
• known history of HIV/AIDS; cancer
• biochemical evidence of renal or hepatic dysfunction; renal or liver disease demyelinating diseases such as multiple sclerosis or amyotrophic lateral sclerosis
• recent blood donation
• clinical history of stroke
• hypertension (systolic > 140 mmHg or diastolic > 90 mmHg)
• type 1 or 2 diabetes; inability to exercise at 50% of predicted heart rate (HR) reserve at baseline
• Participants taking beta-blockers Participants who screen positive for The American Heart Association's contraindications to exercise testing