The overall goal of this proposed study is to assess the reliability of plasticity measured by transcranial magnetic stimulation (TMS) interleaved with intermittent theta-burst stimulation plasticity measures and to assess the influence of an acute bout of aerobic exercise on TMS plasticity measures.

Inclusion Criteria:

• Adult males and females aged 18-70 years old.
• Primary language is English
• Exercise clearance

Exclusion Criteria:

• Presence of cognitive, neurologic or orthopedic conditions that could affect performance of the testing and training procedures
• History of migraines
• History of fainting spells of unknown or undetermined etiology that might constitute seizures
• History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or family history of treatment resistance epilepsy
• Any current history of psychiatric illness
• Any unstable medical condition
• No medication is an absolute exclusion from TMS. Medications will be reviewed by the Principal Investigator and a decision about inclusion will be made based on the following:
• The subject's past medical history, drug does, history of recent medication changes or duration of treatment, and combination with other central nervous system active drugs.
• The published TMS guidelines review medications to considered with TMS (Rossi, Hallet, Rossini, Pascual-Leone, & Safety of TMS Consensus Group, 2009)
• Any metal in the brain, skull or elsewhere unless approved by the responsible MD
• Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant, vagal nerve stimulator)
• Intracranial lesion
• Substance abuse or dependence within the past six months