Comparison Between Hypoglycemic Counter Regulatory Responses in Type 1 Diabetics vs Control Subjects

A Comparison Between Counter Regulatory Responses in Type 1 Diabetic Patients Versus Healthy Control Subjects With and Without Antecedent Hypoglycemia

This study compares the hypoglycemic counter regulatory response in type 1 diabetics and in healthy control subjects with and without antecedent hypoglycemia

Iatrogenic hypoglycemia is one of the main limiting factors for optimal glycemic management of diabetes. It causes recurrent morbidity in most people with type 1 diabetes and in many patients with type 2 diabetes and can be fatal. Episodes of hypoglycemia impair physiologically protective mechanism in subsequent episodes of hypoglycemia. This phenomenon is known as hypoglycemia-associated autonomic failure (HAAF), the clinical syndromes of defective glucose counter regulation and hypoglycemia unawareness.

Type 1 diabetics

Inclusion Criteria:

• More than 5 years of disease duration
• HbA1c 42-86 mmol/L
• No known HAAF
• BMI 22-28
• Written consent

Exclusion Criteria:

• Other disease than diabetes f.x epilepsy, ischemic heart disease or heart rhythm disturbance
• Medication f.x beta-blockade, steroids, psychotropics
• Smoking
• Drug abuse

Control subjects

Inclusion Criteria:

• BMI 22-28
• Written consent

Exclusion Criteria:

• Diseases f.x diabetes, epilepsy, ischemic heart disease or heart rhythm disturbance
• Medication f.x beta-blockade, steroids, psychotropics
• Smoking
• Drug abuse