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| Name | Class |
|---|---|
| Sahlgrenska University Hospital | OTHER |
| The Göteborg Medical Society, Sweden | UNKNOWN |
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The occurrence of dysphagia is a well-known early feature of esophageal cancer that may reduce caloric intake and thus cause weight loss. Sarcopenia is considered to be a consequence of such involuntary nutritional restriction. The prevalence of sarcopenia in patients with esophageal cancer before and after surgery is not well known and its possible consequences have been debated.
Aim: The aim of this study was to prospectively explore body composition and function in a cohort of patients with esophageal cancer before and after surgery with curative intent. In particular, to investigate the prevalence and development of sarcopenia and body composition as a consequence to surgery for esophageal cancer and the possible relation to morbidity, length of stay and quality of life (QoL).
Methods: In a cohort of 76 patients who had esophageal- or cardia-cancer and were planned for surgery with a curative intent, data on body-composition measured with bioimpedance, working capacity (cardiac stress test), grip strength and QoL (European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaires (QLQ)-C30 version 3.0) were prospectively collected. Data regarding dysphagia was derived from an esophagus related quality of life form (EORTC QLQ-OES18). Data on tumour stage and type, complications, length of stay and preoperative weight loss were collected from medical charts.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resection of the esophagus and the gastroesophageal junction | Procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Body composition after surgery for esophageal cancer with curative intent. | Body mass index (BMI) kg/m2 | Three months |
| Changes in Body composition after surgery for esophageal cancer with curative intent | Weight kg | Three months |
| Changes in Body composition after surgery for esophageal cancer with curative intent. | Fat free mass (FFM) kg; | Three months |
| Changes in Body composition after surgery for esophageal cancer with curative intent. | Fat mass (FM) kg; | Three months |
| Changes in Body composition after surgery for esophageal cancer with curative intent. | Lean tissue mass (LTM) kg; | Three months |
| Changes in Body composition after surgery for esophageal cancer with curative intent. | Total body water (TBW) l; | Three months |
| Changes in Body composition after surgery for esophageal cancer with curative intent. | Intra cellular water (ICW) l; | Three months |
| Changes in Body composition after surgery for esophageal cancer with curative intent. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in QoL (linear scale 0-100) | From surgery up to three months | |
| Changes in dysphagia (linear scale 0-100) | From surgery up to three months | |
| Length of stay (days) |
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Inclusion Criteria:
Exclusion Criteria:
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The study was a prospective collected cohort study in 76 patients who were referred to the surgery clinic at the Sahlgrenska University hospital 2005-2010. Patients with esophageal cancer or cancer of the gastroesophageal junction (Siewert I or II), who were scheduled to undergo resection surgery with curative intent, were asked to participate. Patients were excluded if they were found to have an advanced tumour stage or if they declined participation.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Surgical Department, Sahlgrenska University Hospital | Gothenburg | Västra Götalandsregionen | 41345 | Sweden |
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| ID | Term |
|---|---|
| D004938 | Esophageal Neoplasms |
| D013274 | Stomach Neoplasms |
| D055948 | Sarcopenia |
| D003680 | Deglutition Disorders |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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Extra cellular water (ECW) l
| Three months |
| From surgery up to three months |
| Complications after surgery (Clavien-Dindo scale 0-5) | From surgery up to three months |
| Mortality | Length of survival after surgery |
| D006258 |
| Head and Neck Neoplasms |
| D004066 | Digestive System Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D013272 | Stomach Diseases |
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D010608 | Pharyngeal Diseases |
| D010038 | Otorhinolaryngologic Diseases |