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| Name | Class |
|---|---|
| Poznan University of Life Sciences | OTHER |
| National Science Centre, Poland | OTHER_GOV |
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The purpose of this study was to verify the effect of 12-week with β-hydroxy-β-methylbutyrate (HMB) and a placebo (PLA) supplementation on body composition, anaerobic and aerobic capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.
The effect of HMB supplementation is of great interest in sport. In view of the inconclusive character of the results of the studies conducted to date and of a relatively low number of studies investigating the effectiveness of HMB supplementation over a longer period on a large population of trained athletes, the aim of this study was to verify the effect of 12-week with HMB and a placebo supplementation on body composition, anaerobic and aerobic capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| β-hydroxy-β-methylbutyrate (HMB) | Experimental | Group taking oral supplementation with calcium salt of β-hydroxy-β-methylbutyric acid produced by Olimp Laboratories. A single capsule contained 1250 mg Ca-HMB, which corresponds to 1000 mg of β-hydroxy-β-methylbutyrate. Interventions: The experimental procedure for each athlete included a 12-week HMB supplementation - 3 capsules of the assigned preparation a day in 3 doses: upon waking, immediately after training, and before sleep. On non-training days, the participants were instructed to consume one serving with each of three separate meals throughout the day. Between the 12-week HMB and PLA or a PLA and HMB treatment, a 10-day washout period was introduced. |
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| Placebo (maltodextrin) | Placebo Comparator | Group taking oral supplementation with placebo (maltodextrin). A single capsule contained 1000 mg of maltodextrin. Interventions: The experimental procedure for each athlete included a 12-week placebo administration - 3 capsules of the assigned preparation a day in 3 doses: upon waking, immediately after training, and before sleep. On non-training days, the participants were instructed to consume one serving with each of three separate meals throughout the day. Between the 12-week HMB and PLA or a PLA and HMB treatment, a 10-day washout period was introduced. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| β-hydroxy-β-methylbutyrate and a placebo supplementation | Dietary Supplement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes of body composition indices after HMB supplementation | Analysis of the fat mass and fat free mass | Baseline and after 12 weeks |
| Changes of body composition indices after placebo treatment | Analysis of the fat mass and fat free mass | Baseline and after 12 weeks |
| Changes of aerobic capacity after HMB supplementation | Baseline and after 12 weeks | |
| Changes of aerobic capacity after placebo treatment | Baseline and after 12 weeks | |
| Changes of anaerobic capacity after HMB supplementation | Baseline and after 12 weeks | |
| Changes of anaerobic capacity after placebo treatment | Baseline and after 12 weeks | |
| Changes of creatine kinase and lactate dehydrogenase activity in blood after HMB supplementation | Baseline and after 12 weeks | |
| Changes of creatine kinase and lactate dehydrogenase activity in blood after placebo treatment | Baseline and after 12 weeks | |
| Changes of testosterone, cortisol and lactate levels in blood after HMB supplementation | Baseline and after 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Statistical evaluation of the significance of differences between the changes in body composition (fat mass and fat free mass) | 1 year | |
| Statistical evaluation of the significance of differences between the changes in aerobic capacity indices | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jan Jeszka, Professor | Department of Hygiene and Human Nutrition, Poznan University of Life Sciences, Poznan, Poland | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Poznan University of Life Sciences, ul.Wojska Polskiego 31 | Poznan | Wielkopolska | 60-624 | Poland |
Shared data will be exclusively related to the level recorded indicators (body composition, aerobic and anaerobic capacity indicators, levels of biochemical markers), without personal data. The data obtained will be attached to scientific publications, depending on the requirements of the journal
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| Changes of testosterone, cortisol and lactate levels in blood after placebo treatment | Baseline and after 12 weeks |
| Statistical evaluation of the significance of differences between the changes in anaerobic capacity indices | 1 year |
| Statistical evaluation of the significance of differences between the changes in creatine kinase and lactate dehydrogenase activity and testosterone, cortisol and lactate levels in blood | 1 year |