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| Name | Class |
|---|---|
| Laboratory of Biochemistry, University François Rabelais of TOURS | UNKNOWN |
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When the kidneys are perfused on perfusion machines before transplantation, the resistance parameters as well as the histological score on the pre-implantation biopsy participate in the evaluation of the quality of the graft. The metabolomic profile of the infusion fluid could provide additional evidence.
The quality of the renal transplant prior to transplantation is essential for the recovery of graft function in the days following transplantation and its long-term survival. When the kidneys are perfused on perfusion machines before transplantation, the resistance parameters as well as the histological score on the pre-implantation biopsy participate in the evaluation of the quality of the graft. The metabolomic profile of the infusion fluid could provide additional evidence.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LifePort® perfusion machine | Other | Metabolomic analysis of the preservation fluid of the graft, donor and recipient urine by nuclear magnetic resonance spectroscopy, and if possible by liquid and gas chromatography coupled with mass spectrometry. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LifePort® perfusion machine | Device | Renal perfusion on LifePort® machine |
|
| Measure | Description | Time Frame |
|---|---|---|
| IGF | Immediate Graft Function (IGF), defined by serum creatinine less than 250 ÎĽM / L at day 7 post-kidney transplant, without requiring dialysis of the recipient patient. | 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| DGF | DGF Delayed graft function : Dialysis need within 7 days post-transplant | 7 days |
| BANFF-1 | Anatomo-pathological classification of the pre-implantation biopsy according to the revised Banff classification 2013 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Franck BRUYERE, MD-PhD | University François Rabelais of TOURS | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Urology CHRU-TOURS | Tours | I&L | 37000 | France | ||
| CHR-ORLEANS Service d'Urologie |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35442245 | Result | Faucher Q, Alarcan H, Sauvage FL, Forestier L, Miquelestorena-Standley E, Nadal-Desbarats L, Arnion H, Venhard JC, Brichart N, Bruyere F, Marquet P, Barin-Le Guellec C. Perfusate Metabolomics Content and Expression of Tubular Transporters During Human Kidney Graft Preservation by Hypothermic Machine Perfusion. Transplantation. 2022 Sep 1;106(9):1831-1843. doi: 10.1097/TP.0000000000004129. Epub 2022 Apr 20. |
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Metabolic assessment in Urine and perfusion liquids
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| PRE-OPERATIONAL |
| BANFF-2 | Anatomo-pathological classification of systematic biopsy at 3 months post-transplant according to the revised Banff classification 2013 | 3 months |
| Orléans |
| Loiret |
| 45100 |
| France |