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Cognitive remediation (CR) is the best treatment to improve neurocognitive abilities for individuals with psychosis, however, there is no gold standard method of cognitive remediation available. Cognitive training refers to the training component of CR in which people practice computerized exercises that train specific cognitive abilities. There is no agreed upon approach within the field as to the type of training that is most effective with some studies, training higher level cognitive abilities, some training perceptual abilities, and others training general cognitive skills. This study will directly compare two competing methods of cognitive training on measures of neurophysiology, neurocognition, functional competence, and real-world functional performance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Executive Training | Experimental | Executive Training (ET) involves training on computerized cognitive exercises that have graded increases in difficulty so that the participant is always challenged. A therapist will be in the room with participants to address any difficulties with the program and facilitate generation of strategies. ET will be delivered in both individual and group settings. |
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| Perceptual Training | Experimental | Perceptual Training (PT) involves training on computerized cognitive exercises that have graded increases in difficulty so that the participant is always challenged. A therapist will be in the room with participants to address any difficulties with the program and facilitate generation of strategies. PT will be delivered in both individual and group settings. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive Remediation - Executive Training | Behavioral | Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as memory, and problem solving ability. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline | Rating scale completed by participants' case managers that rates their ability to perform different everyday tasks | Post-treatment (within 2 weeks following the end of treatment) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Neurocognition - MATRICS Cognitive Consensus Battery (MCCB) from Baseline | The MCCB is the gold standard cognitive assessment for schizophrenia research | Post-treatment (within 2 weeks following the end of treatment) |
| Change in Neurophysiology - EEG from Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Queen's University | Kingston | Ontario | K7L 5P6 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30845819 | Derived | Best MW, Milanovic M, Iftene F, Bowie CR. A Randomized Controlled Trial of Executive Functioning Training Compared With Perceptual Training for Schizophrenia Spectrum Disorders: Effects on Neurophysiology, Neurocognition, and Functioning. Am J Psychiatry. 2019 Apr 1;176(4):297-306. doi: 10.1176/appi.ajp.2018.18070849. Epub 2019 Mar 8. |
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| ID | Term |
|---|---|
| D011618 | Psychotic Disorders |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| Cognitive Remediation - Perceptual Training | Behavioral | Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as attention, and processing speed. |
|
Alpha and Theta band synchronization, p300, mismatch negativity |
| Post-treatment (within 2 weeks following the end of treatment) |
| Functional Competence - Canadian Objective Assessment of Life Skills Brief (COALS-B) from Baseline | Performance based measure of real life functional skills using role-play | Post-treatment (within 2 weeks following the end of treatment) |
| Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline | Rating scale completed by participants' case managers that rates their ability to perform different everyday tasks | Follow-Up (3 months after the end of treatment) |
| Change in Neurocognition - MATRICS Cognitive Consensus Battery (MCCB) from Baseline | The MCCB is the gold standard cognitive assessment for schizophrenia research | Follow-Up (3 months after the end of treatment) |
| Change in Neurophysiology - EEG from Baseline | Alpha and Theta band synchronization, p300, mismatch negativity | Follow-Up (3 months after the end of treatment) |
| Functional Competence - Canadian Objective Assessment of Life Skills Brief (COALS-B) from Baseline | Performance based measure of real life functional skills using role-play | Follow-Up (3 months after the end of treatment) |