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Cognitive remediation (CR) therapies refer to a number of recent developments to use behavioural strategies to improve neurocognitive abilities and improve everyday functioning in mental disorders such as schizophrenia, bipolar disorder, and depression. In this study, we aim to examine whether we can observe CR effects on measures of neuroplasticity, cognition, and functioning when using a rigorous control comparison group. We hypothesize that the active group will exhibit improvements in executive functioning composite scores, improved EEG theta-gamma frequency modulation, and increased EEG alpha power compared to the placebo group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Executive Function Training | Active Comparator | Two weeks of training of cognitive domain of executive functioning Using online program (Scientific Brain Training Pro) Four exercises |
|
| Placebo Training | Placebo Comparator | Two weeks of training with exercises not affecting working memory, information processing speed, or cognitive load Exercises maintain other traditional progressive aspects to preserve appearance of dynamic titration of difficulty levels Using online program (Scientific Brain Training Pro) Four exercises |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Executive Function Training | Behavioral |
| ||
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline executive functioning composite score at post-treatment assessment | Composite score based on four tests of cognition | Pre-training assessment (Week 1) and post-training assessment (Week 4) |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline EEG theta-gamma frequency modulation at post-treatment assessment | Predicted to improve in active CR (cognitive remediation) condition compared to placebo CR | Pre-training assessment (Week 1) and post-training assessment (Week 4) |
| Change from baseline EEG alpha power at post-treatment assessment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Christopher Bowie, PhD, CPsych | Queen's University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Queen's University | Kingston | Ontario | K7L3N6 | Canada |
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| ID | Term |
|---|---|
| D011618 | Psychotic Disorders |
| D009422 | Nervous System Diseases |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| Behavioral |
Placebo version of executive function training |
|
Predicted to increase in active CR (cognitive remediation) condition compared to placebo CR |
| Pre-training assessment (Week 1) and post-training assessment (Week 4) |