Randomized, comparative and prospective study between Conventional Endoscopic Mucosal Resection for the removal of flat or sessile colorectal lesions without previous attempt to resection.

This prospective randomized trial was conducted in 2 academic services: Instituto do Câncer do Estado de São Paulo and Centro de Diagnóstico em Gastroenterologia, both linked to the University of São Paulo. The clinical study was performed in accordance to the Declaration of Helsinki.

Inclusion Criteria:

• Patients age >18 years with sessile or flat Colorectal Lesions (measuring between 10 and 40mm), who consent to this study

Exclusion Criteria:

• Patients who refuse to participate in the study.
• Patients with pedunculated, depressed or mixed lesions.
• Patients with lesions smaller than 10 mm or larger than 40 mm.
• Patients with lesions that are inflammatory, neuroendocrine or stromal at the pathology.
• Patients with lesions that were submitted to prior attempt to endoscopic resection.