Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| International Nut and Dried Fruit Council | UNKNOWN |
| California Dried Plum Board | OTHER |
Not provided
Not provided
Not provided
Not provided
This is a 2-period randomized crossover study with free-living subjects on self-selected diets. The objective of this study is to compare the effects of ¾ cup of a blend of dried plums, figs, dates and raisins (DPFDR) with an isocaloric and macronutrient matched snack food on blood pressure, vascular health and lipids and lipoproteins in 50 participants who are representative of the U.S. population and at risk for cardiovascular disease (overweight/obese, elevated LDL-cholesterol, prehypertension, and/or prediabetes).
The investigators hypothesize that the inclusion of DPFDR in the diet will decrease blood pressure and LDL-cholesterol, and improve artery function (assessed by standard blood pressure measure, 24 hr ambulatory blood pressure, central blood pressure and arterial stiffness) compared to the control group and baseline.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dried Fruit | Experimental | Daily consumption of ¾ cup blend of dried plums, figs, dates and raisins (DPFDR) for 4 weeks |
|
| Control | Experimental | Daily consumption of isocaloric and macronutrient matched snack food for 4 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dried Fruit | Dietary Supplement | Mixture of equal parts 4 dried fruits (figs, raisins, dates, plums) totaling 3/4 cup daily. |
|
| Measure | Description | Time Frame |
|---|---|---|
| LDL Cholesterol | serum low-density cholesterol concentration | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| HDL-cholesterol, non-HDL cholesterol, triglycerides | serum concentrations of HDL and non-HDL cholesterol and triglycerides | 4 weeks |
| Central blood pressure | central systolic and diastolic blood pressure |
| Measure | Description | Time Frame |
|---|---|---|
| Fecal Microbiome | 4 weeks |
Inclusion Criteria:
And, at least one of the following:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Penny Kris-Etherton, PhD | Penn State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Penn State University | University Park | Pennsylvania | 16802 | United States |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| High Carbohydrate Snack | Other | Calorie-matched carbohydrate-rich snack. |
|
| 4 weeks |
| Pulse wave velocity | carotid-femoral pulse wave velocity | 4 weeks |
| Brachial blood pressure | brachial systolic and diastolic blood pressure | 4 weeks |
| Plasma glucose | fasting plasma glucose | 4 weeks |
| High-sensitivity C-reactive protein | serum hs-CRP | 4 weeks |
| Serum insulin | fasting serum insulin | 4 weeks |
| D009750 |
| Nutritional and Metabolic Diseases |