Alcohol Challenge On Liver and Gut Measured by Liver Vein Catheterization. A Pathophysiological Intervention Trial

To investigate the effects of acute alcohol challenge on the gut and liver axis.

To study the role of acute alcohol challenge on the intestine permeability and inflow of bacterial products to the liver in participants with alcoholic liver disease, non-alcoholic steatohepatitis and healthy controls.

Inclusion Criteria:

• Alcoholic liver fibrosis, non-alcoholic steatohepatitis or liver-healthy individuals

And all of following:

• Bodymass > 50 kg
• Able to be fasting and abstinent on the day of intervention
• international ratio <1.5 and platelets >100 x 10^9, 7 days before the intervention day
• Informed consent

Exclusion Criteria:

• Antibiotics during the last 4 weeks
• Total alcohol abstinence
• Desire of total alcohol abstinence
• Other causes of liver disease suspected (viral, autoimmune, haemochromatosis, Wilsons diseases, alfa 1 antitrypsin deficiency or drug induced)
• Cirrhosis
• Insulin dependent diabetes mellitus
• Incapable to follow the protocol instructions
• Pregnancy
• Primary or secondary liver cancer
• Severe comorbidity
• Allergic to the contrast media iohexol