Castration-resistant Prostate Cancer and Intra-prostatic Hormonal Status

Castration-resistant Prostate Cancer and Intra-prostatic Hormonal Status

The main objective of the study is to determine the intra-prostatic concentration of sexual steroids when castration resistance appears in castration-resistant prostate cancer patients compared to patients naif of hormonal treatment

Inclusion Criteria:

• group 1: patients with a locally advanced prostate cancer naif of any hormonal treatment
• group 2: Patients with a castration-resistant prostate cancer resisting defined by a biological progression
• group 2a: without radiotherapy
• group 2b: with radiotherapy
• Affiliated to a social security scheme
• Having given a written consent.

Exclusion Criteria:

• Patient unable to supply a written consent (patient not understanding French, under guardianship patient).
• neuro-endocrine form or sarcomatoid form prostate cancer