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| ID | Type | Description | Link |
|---|---|---|---|
| ISRCTN83240263 | Registry Identifier | ISRCTN |
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| Name | Class |
|---|---|
| European Union | OTHER |
| IRCCS Centro San Giovanni di Dio Fatebenefratelli | OTHER |
| King's College London | OTHER |
| University Hospital, Montpellier |
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This study evaluates the longitudinal health and social outcomes of adolescent mental health service users who are at the transition boundary of their child and adolescent mental health service, and whether the implementation of a model of managed transition at the service boundary benefits them, as compared to usual care.
The MILESTONE study focuses on the period when young people attending a children and adolescents mental health service (CAMHS) need to move on, or "transition", to an adult mental health service (AMHS), if they still require care or treatment. We know from other research that this transition is not always properly managed and that improving the transition process can have a positive impact on the health and well-being of young people in this position. We want to evaluate what impact the different transition experiences have on young people's health and well-being, and whether the process of Managed Transition has any benefits as compared to usual care.
The MILESTONE study is run in eight European countries (UK, Ireland, Belgium, Holland, France, Germany, Italy and Croatia). CAMHS in the study regions are selected to provide the young people in their care that are reaching transition age either usual care or a novel service called "Managed Transition", which includes the use of a new decision support tool, the Transition Readiness and Appropriateness Measure (TRAM). This should help with decision making and enable better transitions by identifying cases for whom transition from CAMHS to AMHS is advisable and appropriate, or who can be safely discharged or referred to a community based service. CAMHS are randomly assigned to provide the intervention of Managed Transition or usual care. The health and well-being of the young people attending these services is assessed at the start of the study and then followed-up for 24 months to see whether they transition to AMHS or are discharged or referred to some other service.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TRAM feedback | Experimental |
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| Usual care | No Intervention | Patients, parent/carers and clinicians in the control arm will complete the TRAM prior to the transition boundary, but the clinicians won't receive any feedback from it nor any information on the benefits of using the decision support tool. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| TRAM feedback | Behavioral |
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| Measure | Description | Time Frame |
|---|---|---|
| Mental health status (need for care) as measured by Health of the Nation Outcome Scale for Children and Adolescents (HoNOSCA - clinician version) at 15 months | The measure will be completed by a trained MILESTONE research assistant taking into account all available sources of information (including the young person, parent/carer, relevant clinician and the medical records) to ensure accuracy of data. | 15 months |
| Measure | Description | Time Frame |
|---|---|---|
| Self-rated (i.e. completed by young person) mental health status (need for care) on Health of the Nation Outcome Scale for Children and Adolescents (HONOSCA) | Baseline, 9, 15, and 24 months | |
| Transition outcome assessed by the Transition Related Outcome Measure (TROM) questionnaire |
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Inclusion Criteria:
Young person inclusion:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Swaran P Singh, MD, DM | Warwick Medical School, University of Warwick, UK | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Katholieke Universiteit Leuven | Leuven | Belgium | ||||
| University Hospital Split |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41319312 | Derived | Marcolini F, Magno M, Leone S, Martella D, Leucci AC, Atti AR, Cortese S, De Ronchi D, Dieleman G, Franic T, Gerritsen S, Maras A, McNicholas F, Purper-Ouakil D, Santosh P, Schulze UME, Street C, Singh S, Tremmery S, Tuomainen H, van Bodegom LS, Wolke D, de Girolamo G; MILESTONE Consortium. Bridging Perspectives: Clinician-Adolescent Agreement on Psychopathological Severity in the European MILESTONE Cohort. J Clin Psychol. 2026 Mar;82(3):317-329. doi: 10.1002/jclp.70073. Epub 2025 Nov 30. | |
| 41107439 |
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| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D000092862 | Psychological Well-Being |
| ID | Term |
|---|---|
| D010549 | Personal Satisfaction |
| D001519 | Behavior |
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| OTHER |
| Yulius | UNKNOWN |
| University of Ulm | OTHER |
| KU Leuven | OTHER |
| University College Dublin | OTHER |
| Clinical Hospital Center, Split | OTHER |
| HealthTracker Ltd, UK | UNKNOWN |
| Erasmus Medical Center | OTHER |
| Concentris research management gmbh | UNKNOWN |
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The TROM is a questionnaire completed by the young person, parent/carer and clinician
| Baseline, 9, 15, and 24 months |
| Emotional and behavioural problems assessed by the Achenbach System of Empirically Based Assessment (ASEBA) Youth Self Report (YSR)/Adult Self Report (ASR) questionnaires (young person) | YSR is completed by young people aged 17 years or less; ASR by those 18 years or over | Baseline, 9, 15, and 24 months |
| Emotional and behavioural problems assessed by the Achenbach System of Empirically Based Assessment (ASEBA) Child Behavior Checklist (CBCL) or Adult Behavior Checklist (ABCL) questionnaires (parent/carer) | Parent/carer completes CBCL if young person is 17 years or less; ABCL if young person is 18 years or over | Baseline, 9, 15, and 24 months |
| Illness severity assessed by Clinical Global Impression Severity (CGIS) scale (CGIseverity) | Baseline, 9, 15, and 24 months |
| Quality of life assessed by World Health Organisation Quality of Life Assessment (WHOQOLBREF) | Baseline, 15, and 24 months |
| Independent behaviour assessed by Independent Behaviour During Consultation Scale (IBDCS) | Baseline, 9, 15, and 24 months, if young person is a current service user |
| Illness perception assessed by the Brief Illness Perception Questionnaire (BIPQ) | Baseline and 24 months |
| Barriers to care assessed by Barriers to Care (BtC) checklist | 9, 15, and 24 months, if young person is no longer a service user |
| Transition experience and readiness assessed by On Your Own Feet - Transition Experience Scale (OYOF-TES) | at 9, 15 or 24 months, completed only once at the first assessment after transition |
| Adult functioning assessed by Specific Levels of Functioning Scale (SLOF) | Baseline and 24 months |
| Quality Adjusted Life Years (QALYs) assessed by EuroQol generic quality of life questionnaire (EQ-5D-5L) | Baseline, 9, 15, and 24 months |
| Service use assessed by a MILESTONE specific Client Service Receipt Inventory (CSRI) | Baseline, 9, 15, and 24 months |
| Mental health status as measured by Health of the Nation Outcome Scale for Children and Adolescents (HoNOSCA - clinician version) | The measure will be completed by a trained MILESTONE research assistant taking into account all available sources of information (including the young person, parent/carer, relevant clinician and the medical records) to ensure accuracy of data. | Baseline, 9 months, 24 months |
| Split |
| Croatia |
| CHRU Montpellier-St Eloi hospital | Montpellier | France |
| University of Ulm | Ulm | Germany |
| University College Dublin | Dublin | Ireland |
| IRCCS Fatebenefratelli | Brescia | Italy |
| Yulius Academy | Barendrecht | Netherlands |
| Erasmus Medical Centre | Rotterdam | Netherlands |
| Warwick Medical School, University of Warwick | Coventry | CV4 7AL | United Kingdom |
| King's College London | London | SE5 8AF | United Kingdom |
| Derived |
| Magno M, Martella D, Leone S, Allibrio G, Bertani A, Caselani E, Conti P, Cortese S, Dieleman G, Franic T, Gerritsen S, Maffezzoni D, Margari F, Martinelli O, McNicholas F, Micciolo R, Nacinovich R, Purper Ouakil D, Pastore A, Rinaldi F, Santosh P, Scocco P, Schulze U, Singh S, Squarcia A, Stagi P, Street C, Toffol E, Tuomainen H, van Bodegom LS, Vicari S, de Girolamo G; on behalf the MILESTONE Consortium. Mental health trajectories of adolescents treated with psychotropic medications: insights from the european milestone study. Mol Psychiatry. 2026 Jan;31(1):94-103. doi: 10.1038/s41380-025-03307-3. Epub 2025 Oct 17. |
| 34916319 | Derived | Gerritsen SE, Maras A, van Bodegom LS, Overbeek MM, Verhulst FC, Wolke D, Appleton R, Bertani A, Cataldo MG, Conti P, Da Fonseca D, Davidovic N, Dodig-Curkovic K, Ferrari C, Fiori F, Franic T, Gatherer C, De Girolamo G, Heaney N, Hendrickx G, Kolozsvari A, Levi FM, Lievesley K, Madan J, Martinelli O, Mastroianni M, Maurice V, McNicholas F, O'Hara L, Paul M, Purper-Ouakil D, de Roeck V, Russet F, Saam MC, Sagar-Ouriaghli I, Santosh PJ, Sartor A, Schandrin A, Schulze UME, Signorini G, Singh SP, Singh J, Street C, Tah P, Tanase E, Tremmery S, Tuffrey A, Tuomainen H, van Amelsvoort TAMJ, Wilson A, Walker L, Dieleman GC; Milestone consortium. Cohort profile: demographic and clinical characteristics of the MILESTONE longitudinal cohort of young people approaching the upper age limit of their child mental health care service in Europe. BMJ Open. 2021 Dec 16;11(12):e053373. doi: 10.1136/bmjopen-2021-053373. |
| 32580979 | Derived | Santosh P, Singh J, Adams L, Mastroianni M, Heaney N, Lievesley K, Sagar-Ouriaghli I, Allibrio G, Appleton R, Davidovic N, de Girolamo G, Dieleman G, Dodig-Curkovic K, Franic T, Gatherer C, Gerritsen S, Gheza E, Madan J, Manenti L, Maras A, Margari F, McNicholas F, Pastore A, Paul M, Purper-Ouakil D, Rinaldi F, Sakar V, Schulze U, Signorini G, Street C, Tah P, Tremmery S, Tuffrey A, Tuomainen H, Verhulst F, Warwick J, Wilson A, Wolke D, Fiori F, Singh S; MILESTONE Consortium. Validation of the Transition Readiness and Appropriateness Measure (TRAM) for the Managing the Link and Strengthening Transition from Child to Adult Mental Healthcare in Europe (MILESTONE) study. BMJ Open. 2020 Jun 23;10(6):e033324. doi: 10.1136/bmjopen-2019-033324. |
| 32299401 | Derived | Santosh P, Adams L, Fiori F, Davidovic N, de Girolamo G, Dieleman GC, Franic T, Heaney N, Lievesley K, Madan J, Maras A, Mastroianni M, McNicholas F, Paul M, Purper-Ouakil D, Sagar-Ouriaghli I, Schulze U, Signorini G, Street C, Tah P, Tremmery S, Tuomainen H, Verhulst FC, Warwick J, Wolke D, Singh J, Singh SP; MILESTONE Consortium. Protocol for the development and validation procedure of the managing the link and strengthening transition from child to adult mental health care (MILESTONE) suite of measures. BMC Pediatr. 2020 Apr 16;20(1):167. doi: 10.1186/s12887-020-02079-9. |
| 29866202 | Derived | Tuomainen H, Schulze U, Warwick J, Paul M, Dieleman GC, Franic T, Madan J, Maras A, McNicholas F, Purper-Ouakil D, Santosh P, Signorini G, Street C, Tremmery S, Verhulst FC, Wolke D, Singh SP; MILESTONE consortium. Managing the link and strengthening transition from child to adult mental health Care in Europe (MILESTONE): background, rationale and methodology. BMC Psychiatry. 2018 Jun 4;18(1):167. doi: 10.1186/s12888-018-1758-z. |
| 29042376 | Derived | Singh SP, Tuomainen H, Girolamo G, Maras A, Santosh P, McNicholas F, Schulze U, Purper-Ouakil D, Tremmery S, Franic T, Madan J, Paul M, Verhulst FC, Dieleman GC, Warwick J, Wolke D, Street C, Daffern C, Tah P, Griffin J, Canaway A, Signorini G, Gerritsen S, Adams L, O'Hara L, Aslan S, Russet F, Davidovic N, Tuffrey A, Wilson A, Gatherer C, Walker L; MILESTONE Consortium. Protocol for a cohort study of adolescent mental health service users with a nested cluster randomised controlled trial to assess the clinical and cost-effectiveness of managed transition in improving transitions from child to adult mental health services (the MILESTONE study). BMJ Open. 2017 Oct 16;7(10):e016055. doi: 10.1136/bmjopen-2017-016055. |