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| Name | Class |
|---|---|
| Erasme University Hospital | OTHER |
| Brugmann University Hospital | OTHER |
| Service santé mentale à l'ULB | UNKNOWN |
| Université Libre de Bruxelles |
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This clinical study evaluates risk and protective factor to develop psychopathology in transitional age youth. 300 patients will be recruited at the age of 17 years old and assessed at baseline and 2 years later.
Emerging adults are a particularly at-risk population in mental health. Transitional age youth have specific needs, not currently covered between child and adolescent mental health services (CAMHS) and adult mental health services (AMHS), mainly because of existing barriers. Movements from one to the other must be planned to achieve optimal patient care.
Our project aims to identify clinical dimensional characteristics contributing to the development of psychopathology during the transition period. Continuities, discontinuities and resilience factors will be explored. The final purpose is to develop a non-stigmatizing approach to reduce rejection from youths in psychopathological suffering and increase social inclusion.
The transversal and trans-diagnostic approach consists of a dimensional evaluation: 300 youth at the age of 17 will be included in a cohort of in-patients, out-patients and control group. Participants will be assessed at baseline and 2 years later. The primary outcome is based on Health of the Nation Outcome Scale for Children and Adolescents, measuring mental health care need, and WHO Quality of Life assessment.
The secondary outcomes include the assessment of dimensions representing risk or protective factors to develop psychopathology and evolution of mental health status during transition age. Baseline evaluation consists in internalizing/externalizing symptoms, impulsivity/compulsivity, emotion regulation, cognitive functioning, social and family functioning, developmental, medical and trauma history. At follow-up, mental health pathways and transition results will be described.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Transitional age youth | Other | Assessed group. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Risk and Protective Factors Assessment | Other | First assessment at baseline (T0) - 17 y.o. Follow-up 2 years later (T1) - 19 y.o. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline self-rated mental health status (need for care) at 2 years | Measured at baseline (T0) and follow-up (T1) with the Health of the Nation Outcome Scale for Children and Adolescents (HoNOSCA). | Change from Baseline HoNOSCA before transition at 17 y.o. to after transition at 19 y.o. |
| Change from Baseline self-rated measure of quality of life at 2 years | Measured at baseline (T0) and follow-up (T1) with the Quality of life assessed by World Health Organisation Quality of Life Assessment (WHO-QoL-BREF) | Change from Baseline WHO-QoL before transition at 17 y.o. to after transition at 19 y.o |
| Measure | Description | Time Frame |
|---|---|---|
| Self-rated measure of traumatic life events | Measured with Childhood Trauma Questionnaire (CTQ) | Before transition at 17 y.o. (T0) |
| Self-rated measure of family functioning | Measured with Family Assessment Device (FAD) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Véronique Delvenne, MD, PhD | Queen Fabiola Children's University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Brugmann University Hospital | Brussels | 1020 | Belgium | |||
| Hôpital Universitaire Des Enfants Reine Fabiola |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29621902 | Background | Caspi A, Moffitt TE. All for One and One for All: Mental Disorders in One Dimension. Am J Psychiatry. 2018 Sep 1;175(9):831-844. doi: 10.1176/appi.ajp.2018.17121383. Epub 2018 Apr 6. | |
| 29866202 | Background | Tuomainen H, Schulze U, Warwick J, Paul M, Dieleman GC, Franic T, Madan J, Maras A, McNicholas F, Purper-Ouakil D, Santosh P, Signorini G, Street C, Tremmery S, Verhulst FC, Wolke D, Singh SP; MILESTONE consortium. Managing the link and strengthening transition from child to adult mental health Care in Europe (MILESTONE): background, rationale and methodology. BMC Psychiatry. 2018 Jun 4;18(1):167. doi: 10.1186/s12888-018-1758-z. |
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| ID | Term |
|---|---|
| D000092862 | Psychological Well-Being |
| ID | Term |
|---|---|
| D010549 | Personal Satisfaction |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D012306 | Risk |
| ID | Term |
|---|---|
| D011336 | Probability |
| D013223 | Statistics as Topic |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
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| OTHER |
| King Baudouin Foundation | OTHER |
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| Before transition at 17 y.o. (T0) |
| Self-rated measure to quantify the risk of developing psychiatric disorders | Measured with General Health Questionnaire (GHQ-12) | Before transition at 17 y.o. (T0) |
| Self-rated measure of internalising and externalising symptoms | Measured with Youth Self Report 11-18 (YSR) | Before transition at 17 y.o. (T0) |
| Self-rated measure of impulsivity and compulsivity | Measured with Barratt Impulsiveness Scale (BIS-11) | Before transition at 17 y.o. (T0) |
| Self-rated measure of depressivity | Measured with Beck Depression Inventory-II (BDI-II) | Before transition at 17 y.o. (T0) |
| Self-rated measure of suicidal risk | Measured with Beck Scale of Suicide Ideation (BSS) | Before transition at 17 y.o. (T0) |
| Self-rated measure of emotional regulation | Measured with Emotion Regulation Questionnaire for Children and Adolescents (ERQ-CA) | Before transition at 17 y.o. (T0) |
| Self-rated measure of interpersonal relationships social adaptation | Measured with Social Adaptation Self-evaluation Scale (SASS) | Before transition at 17 y.o. (T0) |
| Self-rated measure of cognitive insight | Measured with Beck Cognitive Insight Scale (BCIS) | Before transition at 17 y.o. (T0) |
| Cognitive assessment - IQ | Measured with Wechsler Adult Intelligence Scale (WAIS-IV) | Before transition at 17 y.o. (T0) |
| Executive functions assessment - alertness, divided attention, flexibility and working memory | Measured with Test of Attentional Performance (TAP) | Before transition at 17 y.o. (T0) |
| Executive functions assessment - cognitive inhibition | Measured with STROOP Task | Before transition at 17 y.o. (T0) |
| Executive functions assessment - planning task | Measured with Tower of London Test (TOL) | Before transition at 17 y.o. (T0) |
| Self-rated measure of executive functions | Measured with Behavior Rating Inventory of Executive Function - Self report (BRIEF-SR) | Before transition at 17 y.o. (T0) |
| Self-rated measure of transition readiness and appropriateness | Measured with Transition Readiness and Appropriateness Mesure (TRAM) | Before transition at 17 y.o. (T0) |
| Self-rated measure of therapeutic alliance | Measured with Helping Alliance Questionnaire (HAQ) | After transition at 19 y.o. (T1) |
| Self-rated measure of transition related outcomes | Measured with Transition Related Outcomes Mesure (TROM) | After transition at 19 y.o. (T1) |
| Brussels |
| 1020 |
| Belgium |
| Service santé mentale à l'ULB | Brussels | 1050 | Belgium |
| Erasme University Hospital | Brussels | 1070 | Belgium |
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| 37032919 | Derived | Marchini S, Reis J, Ben-Shaool E, Delhaye M, Kornreich C, Nicolis H, Slama H, Leys C, Delvenne V. Dimensional model on how familial vulnerability and environmental factors impact transitional age youth psychopathology: The Transition_psy study. Front Psychiatry. 2023 Mar 23;14:1103030. doi: 10.3389/fpsyt.2023.1103030. eCollection 2023. |
| 34234697 | Derived | Reis J, Marchini S, De Leeuw A, Slama H, Leys C, Delhaye M, Kornreich C, Nicolis H, Delvenne V. Study Protocol: Transition_psy a Multicenter Prospective Longitudinal Cohort Study Assessing Risk and Protective Factors to Develop Psychopathology in Transitional Age Youth in Belgium. Front Psychiatry. 2021 Jun 21;12:645679. doi: 10.3389/fpsyt.2021.645679. eCollection 2021. |
| D055641 |
| Mathematical Concepts |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |