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This study aims to conduct a contrast study on the characteristics of functional and structural connectivity of neural networks of working memory in patients with acquired brain injury versus normal controls, using resting-state functional connectivity magnetic resonance imaging, task-specific functional magnetic resonance imaging and diffusion tensor imaging, combined with cognitive behavioral examinations. Another purpose is to reveal the characteristics of dynamic change of neural networks of working memory pre- and post-intervention in patients with working memory dysfunction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Working Memory Training | Experimental | The subjects of experimental group received a series of working memory training, 30 min for 5 days per week during 6 weeks. |
|
| Non-Working Memory Training | No Intervention | The subjects of control group performed traditional cognitive rehabilitation without working memory training, 30 min for 5 days per week during 6 weeks. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Working memory training | Behavioral |
|
| Measure | Description | Time Frame |
|---|---|---|
| Training-induced brain activations during working memory tasks in fMRI | Training-induced increased and decreased brain activations (Number of voxels) during n-back verbal WM task compared to the pre-training baseline | six weeks |
| Measure | Description | Time Frame |
|---|---|---|
| The fluid intelligence measured by Raven's Standard Progressive Matrices (RSPM) test | six weeks | |
| Attention ability assessed by Stroop color-word test | six weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xiaoping Yun, MD | Contact | 86-01067574465 | xiaoping_yun@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Xiaoping Yun, MD | Department of Rehabilitation Evaluation, China Rehabilitation Research Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Rehabilitation Evaluation, China Rehabilitation Research Center | Recruiting | Beijing | Beijing Municipality | 100068 | China |
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