The Neural Substrates for Working Memory Training

The Study on the Brain Mechanisms for the Rehabilitation of Working Memory Deficits in Patients With Acquired Brain Injury Using Multimodal Magnetic Resonance Imaging

This study aims to conduct a contrast study on the characteristics of functional and structural connectivity of neural networks of working memory in patients with acquired brain injury versus normal controls, using resting-state functional connectivity magnetic resonance imaging, task-specific functional magnetic resonance imaging and diffusion tensor imaging, combined with cognitive behavioral examinations. Another purpose is to reveal the characteristics of dynamic change of neural networks of working memory pre- and post-intervention in patients with working memory dysfunction.

Inclusion Criteria:

• Right handedness
• Diagnosis of traumatic brain injury or stroke
• Course of disease within one year
• The score of MoCA test > 24
• Able to understand instructions

Exclusion Criteria:

• Aphasia, unilateral spatial neglect, agnosia, apraxia
• Hearing impairment or visual impairment
• History of taking psychiatric drugs