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Study terminated due to lack of funding
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This study will evaluate the efficacy of working memory training in older adults with amnestic mild cognitive impairment (MCI).
Working memory (WM) is the ability to hold information actively in mind and is fundamental for higher-order cognition. This pilot study aims to (1) evaluate the efficacy of WM training in older adults with MCI and (2) understand if and how it works. The study will use behavioral and brain imaging assessments to see whether WM training changes how participants learn and remember information. Functional magnetic resonance imaging (fMRI) and functional near infrared spectroscopy (fNIRS) methods will be used. The study will also use cognitive tests and questionnaires to determine whether participants' cognitive abilities change with training. The study will enroll participants with a diagnosis of MCI as well as cognitively intact older adults (healthy controls, HC).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| In-Person, MCI | Active Comparator | Participants diagnosed with MCI will undergo 10 sessions of WM training in person. |
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| Online, MCI | Active Comparator | Participants diagnosed with MCI will undergo 10 sessions of WM training online. |
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| Online, Healthy | Active Comparator | Cognitively intact older adults will undergo 10 sessions of WM training online. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Working Memory Training | Behavioral | A 10-session working memory (WM) training program |
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| Measure | Description | Time Frame |
|---|---|---|
| Gains in WM training task performance | Analyses of WM performance for each training session indexed as the mean set-size achieved during each training session for each participant | 2 weeks |
| Changes in brain activation within the WM network | Univariate analyses via fMRI and fNIRS, respectively, using units of brain activation (i.e., contrast estimates) | 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in criterion (fMRI) WM task performance | Analyses of WM performance indexed as percent accuracy | 2 weeks |
| Changes in functional connectivity within and between canonical brain networks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alexandru Iordan, Ph.D. | University of Michigan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Michigan | Ann Arbor | Michigan | 48109 | United States |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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Participants in the MCI group will be assigned to receive either in-person (Arm1) or online WM training (Arm2), based on their preference and availability of equipment ensuring a stable internet connection, for 10 training sessions. Participants in the HC group will receive online training (Arm3). Data for HC who received in-person training was already collected (HUM00033133). WM performance in conjunction with brain imaging will be assessed within-subject, twice pre-training (Time1 and Time2) and once post-training (Time3), as well as ~1 month after training (Follow-up). The Time1 vs. Time2 comparison will reveal task-exposure effects, whereas the Time2 vs. Time3 comparison will reveal training effects.
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Graph theory analysis via fMRI and fNIRS, respectively, using measures of connectivity strength (i.e., correlation coefficients)
| 2 weeks |