Memory Training and Neural Plasticity

Working Memory Training and Neural Plasticity in Mild Cognitive Impairment

This study will evaluate the efficacy of working memory training in older adults with amnestic mild cognitive impairment (MCI).

Working memory (WM) is the ability to hold information actively in mind and is fundamental for higher-order cognition. This pilot study aims to (1) evaluate the efficacy of WM training in older adults with MCI and (2) understand if and how it works. The study will use behavioral and brain imaging assessments to see whether WM training changes how participants learn and remember information. Functional magnetic resonance imaging (fMRI) and functional near infrared spectroscopy (fNIRS) methods will be used. The study will also use cognitive tests and questionnaires to determine whether participants' cognitive abilities change with training. The study will enroll participants with a diagnosis of MCI as well as cognitively intact older adults (healthy controls, HC).

Inclusion Criteria:

• MCI Diagnosis
• Right-handedness
• MRI-eligibility for MRI participants

Exclusion Criteria:

• History of other contributing neurological or medical conditions known to affect cognitive functioning
• Significant mental illness
• Sensory impairments that limit ability to participate
• History of alcohol or drug abuse/dependence