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Obstructive sleep apnea (OSA) is a common clinical condition associate with a negative impact not limited to the patients but also to the partner that sleep in the same bed. Is it reasonable to speculate that the partner suffer sleep deprivation, increased level of irritability, insomnia, fatigue, among others due to the loud snoring caused by the OSA patient. Although previous data reported impaired sleep quality in partners of patients with OSA, it is not clear in literature whether OSA promotes cardiovascular impact and if the treatment of OSA promotes some cardiovascular benefits in (the) partner beyond the improvements in the subjective and objective sleep. Thus, the main objectives of this randomized controlled study are: to evaluate the impact of three months of randomization (treatment with nasal CPAP or nasal strips) on the endothelial function, blood pressure (ambulatory blood pressure monitoring), sleep duration (wrist actigraphy for 1 week) and sleep quality (Pittsburgh Questionnaire) and the frequency of OSA in the bed partners of patients with moderate to severe OSA.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CPAP (in the partner) | Active Comparator | Positive airway pressure for treating OSA in the bed partner. |
|
| Nasal strips (in the partner) | Placebo Comparator | Nasal dilator as a placebo for treating OSA in the bed partner. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Continuous positive airway pressure (CPAP) | Device | Standard treatment for sleep apnea |
|
| Measure | Description | Time Frame |
|---|---|---|
| Endothelial function (forearm dilation, FMD - %) | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Sleep quantity (measured by actigraphy - hours/night) | 1 week of wrist actigraphy | 3 months |
| Sleep quality (Pittsburgh Questionnaire) | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Luciano Drager | São Paulo | Brazil |
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| ID | Term |
|---|---|
| D012891 | Sleep Apnea Syndromes |
| ID | Term |
|---|---|
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
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| ID | Term |
|---|---|
| D045422 | Continuous Positive Airway Pressure |
| ID | Term |
|---|---|
| D011175 | Positive-Pressure Respiration |
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D013812 | Therapeutics |
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| Nasal strip | Device | Placebo |
|
| Ambulatory blood pressure monitoring (ABPM) | 3 months |
| Frequency of OSA | Baseline only |
| D020920 |
| Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D012138 |
| Respiratory Therapy |