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| Name | Class |
|---|---|
| Fleury | UNKNOWN |
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Obstructive Sleep Apnea (OSA) is a common condition that may induce hemodynamic and metabolic dysregulation. However, it is not clear if OSA is a mere epiphenomenon or contributes to increase the morbidity associated with metabolic syndrome. This study was designed to evaluate the impact of OSA treatment with CPAP in consecutive patients with metabolic syndrome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CPAP | Experimental | CPAP: Continuous Positive Airway Pressure - Device used for treating OSA during sleep. |
|
| Placebo | Placebo Comparator | Nasal Strips |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CPAP (REMstar System One Plus - Philips Medical Systems) | Device | Standard device for treating obstructive sleep apnea. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Reversibility of Metabolic Syndrome criteria | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Abdominal fat | Abdominal CT | 6 months |
| Hepatic steatosis | Abdominal CT | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Luciano F Drager, MD, PhD | Heart Institute (InCor), University of Sao Paulo Medical School | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Luciano Drager | São Paulo | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35063452 | Derived | Giampa SQC, Furlan SF, Freitas LS, Macedo TA, Lebkuchen A, Cardozo KHM, Carvalho VM, Martins FC, Azam IFB, Costa-Hong V, Lopes HF, Baptista ML, Rochitte CE, Bortolotto LA, Lorenzi-Filho G, Drager LF. Effects of CPAP on Metabolic Syndrome in Patients With OSA: A Randomized Trial. Chest. 2022 May;161(5):1370-1381. doi: 10.1016/j.chest.2021.12.669. Epub 2022 Jan 19. |
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| ID | Term |
|---|---|
| D012891 | Sleep Apnea Syndromes |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
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| ID | Term |
|---|---|
| D045422 | Continuous Positive Airway Pressure |
| ID | Term |
|---|---|
| D011175 | Positive-Pressure Respiration |
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D013812 | Therapeutics |
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| Nasal strips | Device |
|
| carotid intima-media thickness | Carotid ultrasound | 6 months |
| endothelial function | Braquial artery ultrasound (flow mediated dilation, %) | 6 months |
| coronary atherosclerosis | Coronary CT | 6 months |
| Inflammatory markers | C-reactive protein | 6 months |
| Metabolomics | Metabolomic analysis (intended to be a sub-study) | 6 months |
| MicroRNAs | MicroRNAs analysis (intended to be a sub-study) | 6 months |
| Epicardic fat | Epicardic fat quantification by CT (intended to be a sub-study) | 6 months |
| Heart remodeling | Evaluated by Tranthoracic echocardiography (intended to be a sub-study) | 6 months |
| D020920 |
| Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D012138 |
| Respiratory Therapy |