Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| TAKARA BIOTECHNOLOGY(DALIAN)CO.,LTD. | UNKNOWN |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study investigates the relationship of circulating microRNA-30e and schizophrenia, and shows the relevance of the aberrant microRNA-30e expression in plasma with the variation disease status.
The plasma samples from 15 individuals with schizophrenia (with a diagnosis of ICD-10) and the equivalent healthy controls will be conducted with the quantification analysis of the microRNA-30e via real-time quantitative polymerase chain reaction(RT-PCR).
The 15 patients enrolled should be the first-episode and have not been treated, or were drug free 3 months recently at least.
This research measures the expression level of microRNA-30e in schizophrenia respectively before the beginning treatment with atypical psychotics or combined with MECT, after the 4-week treated , the 8-week treated compared with 15 healthy controls.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| schizophrenia | 15 patients with schizophrenia will be treated with anyone of the atypical psychotics(including olanzapine, quetiapine , ziprasidone and risperidone)or combined with MECT. The fluctuating dosage depends on the changes of symptom according to the total scores of Positive and Negative Syndrome Scale from schizophrenia patients after treated. |
| |
| health controls | 15 healthy individuals were collected from Dalian seventh people's hospital and were matched on age and sex to schizophrenia group |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Atypical Antipsychotic | Drug | Olanzapine: tablet ,5-20mg, Po q.d. Risperidone: tablet ,1-3 mg, Po q.d. Quetiapine: tablet ,100-400mg, Po b.i.d. ziprasidone : tablet ,40 -80mg, Po b.i.d. |
| Measure | Description | Time Frame |
|---|---|---|
| the Baseline expression profiling of microRNA-30e measured by real-time quantitative poly-chain reaction (QPCR) | the plasma samples will be collected from the patients with schizophrenia and the healthy controls at the beginning recruit for the microRNA-30e detection | before the treatment |
| the Changed expression level of microRNA-30e measured by real-time quantitative poly-chain reaction (QPCR) | the plasma samples will be collected from the patients with schizophrenia at the 4-week treatment for the microRNA-30e detection | Change from Baseline expression level at 4-week treatment |
| the Changed expression level of microRNA-30e measured by real-time quantitative poly-chain reaction (QPCR) | the plasma samples will be collected from the patients with schizophrenia at the 8-week treatment for the microRNA-30e detection | Change from Baseline expression level at 8-week treatment |
| Measure | Description | Time Frame |
|---|---|---|
| the scores of Positive and Negative Syndrome Scale(PANSS) for the patients with schizophrenia | The PANSS for estimating the severity of positive and negative symptoms in schizophrenia | before, after 4 weeks and 8 weeks treatment |
| The degree of Personal and Social Performance scale(PSP) for the patients with schizophrenia |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
the first-onset schizophrenia patients or drug-free suffers in the last 3 months，who are Chinese of Han descent and admitted to the Dalian Seventh People's Hospital,China
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guanghui Fu, postgraduate | Contact | 86-188 4282 1307 | fuguanghui1023@126.com | |
| Shoufu Xie, postgraduate | Contact | 86-0411 8451 4015 | doctorxie1023@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Shoufu Xie, postgraduate | Dalian Seventh People's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dalian Seventh People's Hospital | Recruiting | Dalian | Liaoning | 116023 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27258654 | Result | Xu C, Liu X, Song X, Gao Q, Cheng L, Wang L, Zhang K, Xu Y. Aberrant resting state in microRNA-30e rat model of cognitive impairment. Neuroreport. 2016 Aug 3;27(11):809-17. doi: 10.1097/WNR.0000000000000616. | |
| 20347265 | Result | Xu Y, Li F, Zhang B, Zhang K, Zhang F, Huang X, Sun N, Ren Y, Sui M, Liu P. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. Schizophr Res. 2010 Jun;119(1-3):219-27. doi: 10.1016/j.schres.2010.02.1070. Epub 2010 Mar 27. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D008844 | Micrognathism |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
| D007569 | Jaw Abnormalities |
| D007571 | Jaw Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D000077152 | Olanzapine |
| D000069348 | Quetiapine Fumarate |
| C092292 | ziprasidone |
| D018967 | Risperidone |
| ID | Term |
|---|---|
| D001569 | Benzodiazepines |
| D001552 | Benzazepines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
Not provided
Not provided
Not provided
Not provided
Not provided
The peripheral blood sample Plasma separated from the peripheral blood
|
| atypical antipsychotic combined with MECT | Other | The schizophrenia who matches the indications such as severe negativism, refused to eating or stupor may be treated with antipsychotic combined with MECT, the frequency and times of MECT depend on the state of illness |
|
|
The degree of Personal and Social Performance scale(PSP) used to evaluate the disable levels in Multiple dimensions ,especially in social and self-care performance |
| before, after 4 weeks and 8 weeks treatment |
| The scale of Clinical Global Impression(CGI) in patients with schizophrenia after treatment | Main purpose to provide a global rating of illness severity ,improvement and response to treatment for the patients with schizophrenia | 4 weeks and 8 weeks treatment |
| 23382797 | Result | Banigan MG, Kao PF, Kozubek JA, Winslow AR, Medina J, Costa J, Schmitt A, Schneider A, Cabral H, Cagsal-Getkin O, Vanderburg CR, Delalle I. Differential expression of exosomal microRNAs in prefrontal cortices of schizophrenia and bipolar disorder patients. PLoS One. 2013;8(1):e48814. doi: 10.1371/journal.pone.0048814. Epub 2013 Jan 30. |
| D009140 | Musculoskeletal Diseases |
| D019767 | Maxillofacial Abnormalities |
| D019465 | Craniofacial Abnormalities |
| D009139 | Musculoskeletal Abnormalities |
| D009057 | Stomatognathic Diseases |
| D018640 | Stomatognathic System Abnormalities |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D006571 | Heterocyclic Compounds |
| D003987 | Dibenzothiazepines |
| D013841 | Thiazepines |
| D013846 | Thiepins |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D006575 | Heterocyclic Compounds, 3-Ring |
| D011744 | Pyrimidinones |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |