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Peritoneal dialysis (PD) is one of established treatments in the end stage renal disease patients. Volume overload is a predictor of mortality in PD patients. In this Randomized controlled trial, the investigators use the Body Composition Monitor (BCM), a multifrequency bioimpedance device, to measure the level of overhydration in PD patients and explore its value in fluid management in peritoneal dialysis patients as well as their prognosis.
Optimal fluid management is one of the primary objectives of dialysis treatment, and there is significant concern that peritoneal dialysis (PD) patients can become progressively fluid-loaded with time on treatment, especially as residual kidney function declines. Body Composition Monitor (BCM) has the potential to enable better management of fluid balance. The investigators undertake a prospective, randomized, open-label, controlled trial to determine whether availability of longitudinal BCM measures help clinicians maintain stable fluid status over 24 months in 300 peritoneal dialysis patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| clinical group | Active Comparator | evaluate the volume status just according to clinical indexes in this group. |
|
| clinical and BCM group | Experimental | Both body composition monitor (BCM) and clinical indexes are used to evaluate the volume status of patients in this group. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Body composition monitor | Device | Both body composition monitor (BCM) is used to evaluate the volume status of patients. |
|
| Measure | Description | Time Frame |
|---|---|---|
| volume status | change in overhydration(OH) value | 96 weeks |
| The incidence of cardiovascular events | different incidence of cardiovascular diseases | 96 weeks |
| patient mortality | different rates of all-cause patient mortality and cardiovascular mortality | 96 weeks |
| technique failure | different incidence of technique failure during peritoneal dialysis treatment | 96 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| blood pressure | change in blood pressure | 96 weeks |
| residual renal function | decline rate of residual renal function | 96 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Wei Fang, Dr | Department of Nephrology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of nephrology , Renji Hospital, Shanghai Jiao Tong University School of Medicine | Shanghai | Shanghai Municipality | 200127 | China |
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| ID | Term |
|---|---|
| D007676 | Kidney Failure, Chronic |
| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
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| clinical indexes | Device | The investigators evaluate the volume status of patients according to clinical indexes. |
|
| peritoneal function | differences of peritoneal solute transport rate | 96 weeks |
| heart function | differences of ejection fraction (EF) in echocardiography | 96 weeks |
| D052776 |
| Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |