Control Of Fluid Balance Guided by Body Composition Monitoring in Patients on PeritoneAl dialySiS

Control Of Fluid Balance Guided by Body Composition Monitoring in Patients on PeritoneAl dialySiS (COMPASS) Trial

Bioimpedance-guided fluid management in peritoneal dialysis patients may provide better protection of residual renal function over 1 year period, compared with management guided by clinical information alone - such as blood pressure, body weight, and physician's physical examination.

Inclusion Criteria:

• age bwten 20 and 75
• peritoneal dialysis > 4 weeks duration
• written consent
• daily urine output > 500 ml

Exclusion Criteria:

• subjects who are contraindicated to the bioimpedance measurement (pacemaker insertion state, defibrillator state, amputee, prosthesis, metal implants)
• pregnant women
• subjects who are expected to discontinue peritoneal dialysis with one year
• mixed dialysis modality (peritoneal + hemodialysis)
• hypoalbuminemic subjects (serum albumin < 3.3 g/dL)
• high blood pressure (> 160/100 mmHg despite antihypertensive medications)
• severe heart failure (NYHA FC III, or IV)