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| ID | Type | Description | Link |
|---|---|---|---|
| OCR18886 | Other Identifier | University of Florida |
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The long-term goal of this study is to evaluate cognitive function preoperatively and develop techniques of intervention in the perioperative period which would optimize brain function and functional recovery following surgery.
In this protocol, subjects who are anticipated to be operated for hip fracture will be studied after surgery. Brief cognitive exam will be done followed by fMRI of connectivity and diffusion tensor imaging (DTI). Connectivity (neuronal changes) and DTI (Anisotropy and mean diffusivity) data will be compared with age matched controls and correlated with subjective measures of cognition.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Elderly Hip Fracture | Experimental | Postoperative assess cognitive function in elderly subjects after fracture hip surgery. Measure function connectivity and DTI (diffusion tensor imaging) via: fMRI. Subjective measures will include: Montreal Cognitive Assessment (MoCA), Digital Clock Drawing Test Command and Copy, Wide Range Achievement Test reading subtest, Hopkins Verbal Learning Test (HVLT), General Depression Scale (GDS) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fMRI | Behavioral | fMRI for measuring function connectivity and DTI will be done between day 2 to day 5. |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes between baseline and follow up visits as assessed by fMRI | fMRI for measuring function connectivity and DTI | Change from baseline up to 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| Changes between baseline and follow up visits as assessed by MoCA | A measure of general cognition | Change from baseline up to 90 days |
| Changes between baseline and follow up visits as assessed by Digital Clock Drawing Test Command and Copy |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ramachandran Ramani, MD | University of Florida | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UF Health | Gainesville | Florida | 32610 | United States |
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| Montreal Cognitive Assessment (MoCA) | Behavioral | A measure of general cognition |
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| Digital Clock Drawing Test Command and Copy | Behavioral | A measure of current cognition using digital pen technology |
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| Wide Range Achievement Test reading subtest | Behavioral | A measure of premorbid intellectual estimate |
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| Hopkins Verbal Learning Test (HVLT) | Behavioral | A measure of declarative memory |
|
| General Depression Scale (GDS) | Behavioral | A measure of the of presence of depression. |
|
a measure of current cognition using digital pen technology
| Change from baseline up to 90 days |
| Changes between baseline and follow up visits as assessed by Wide Range Achievement Test reading subtest | A measure of premorbid intellectual estimate | Change from baseline up to 90 days |
| Changes between baseline and follow up visits as assessed by HVLT | A measure of declarative memory | Change from baseline up to 90 days |
| ID | Term |
|---|---|
| D000071257 | Emergence Delirium |
| D000079690 | Postoperative Cognitive Complications |
| ID | Term |
|---|---|
| D003693 | Delirium |
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D060825 | Cognitive Dysfunction |
| D003072 | Cognition Disorders |
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| ID | Term |
|---|---|
| D000073216 | Mental Status and Dementia Tests |
| D004261 | DNA Replication |
| ID | Term |
|---|---|
| D009483 | Neuropsychological Tests |
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |
| D001669 | Biochemical Phenomena |
| D055598 | Chemical Phenomena |
| D055614 | Genetic Phenomena |
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