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An assessment of the feasibility of structural and functional magnetic resonance imaging (MRI) brain scans in older people who have recovered from and older people who never had delirium after hip fracture surgery
Postoperative delirium, an acute sate of confusion occurs with higher frequency in older people. Hip fracture surgery is a procedure associated with an increased risk of postoperative delirium.
In the study the feasibility of achieving structure and functional connectivity imaging of the brain, using magnetic resonance imaging, in older people who are recovering from hip fracture surgery will be assessed.
People who have recovered from post operative delirium and people who did not have postoperative delirium will be included.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Never had delirium | Older people recovering from hip fracture surgery who did not have postoperative delirium |
| |
| Recovered delirium | Older people recovering from hip fracture surgery who experienced delirium which has resolved |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Functional MRI | Diagnostic Test | Series of MRI scans of the brain |
|
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility of MRI in older people following hip fracture surgery assessed by tolerability of transfer to scanner and the scanning process | The feasibility of transferring participants to and achieving structural and functional MRI scans. Specifically we will assess the number of participants in whom scans were successfully achieved | From time of consent to day after MRI scan which is up to 5 days |
| Measure | Description | Time Frame |
|---|---|---|
| Abnormalities of functional connectivity | Identify any differences in functional connectivity between the resolved delirium and the never delirium MRI scans | Up to one month after scans have been achieved |
| Pain assessment. |
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Inclusion Criteria:Age
Exclusion Criteria:
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Older people recovering from hip fracture surgery
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Abiodun Moronke Noah, FRCA | Contact | 01158231011 | abi.noah@nottingham.ac.uk | |
| Iain K Moppett, DM | Contact | 01158230959 | iain.moppett@nottingham.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Rob Dineen, PhD | University of Nottingham | Principal Investigator |
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Incidental findings in participants who give consent for sharing of these with their physician, will be communicated to the general practitioner for further action if required.
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| ID | Term |
|---|---|
| D006620 | Hip Fractures |
| D000071257 | Emergence Delirium |
| ID | Term |
|---|---|
| D005264 | Femoral Fractures |
| D050723 | Fractures, Bone |
| D014947 | Wounds and Injuries |
| D025981 | Hip Injuries |
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| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| ID | Term |
|---|---|
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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An assessment of baseline pain levels and then repeat assessments of pain during transfer and the MRI scanning process using the numerical pain rating scale
| From immediately prior to transfer to the MRI suite until return to own hospital bed which is approximately 2 hours |
| Actual times taken to achieve scans | An assessment of unforeseen constraints on time taken to scan | Up to 60 minutes |
| Participant feedback | The participant experience will be explored via verbal feedback which will be documented by the accompanying researcher | Two occassions. The first immediately after return from the MRI scan suite. The second will occur the day after scanning. Each will take 5 minutes. |
| D007869 |
| Leg Injuries |
| D003693 | Delirium |
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |