Ozone Therapy for Masticatory Muscle Pain (OTMMP)

Effect of High-frequency Bio-oxidative Ozone Therapy for Masticatory Muscle Pain: a Double-blind Randomized Clinical Trial

This study investigates the efficacy of bio-oxidative ozone application in the treatment of TMD of muscular origin.

Ozone is a natural pale blue gas that can be found in the atmosphere. Medical grade ozone is a powerful oxidizing agent which can be produced commercially in ozone generators. Ozone can have effects on blood components and positively affect oxygen metabolism, cell energy, immunomodulation and microcirculation.

Inclusion Criteria:

• Diagnosis of myofascial pain according to the Research Diagnostic Criteria for Temporomandibular Disorder (RDC/TMD)
• Natural posterior occlusion.

Exclusion Criteria:

• Any TMJ internal derangement
• Inflammatory connective tissue disease
• Psychiatric problem
• Tumour
• Hearth disease or pacemaker
• Pregnancy
• Other orofacial region disease symptoms (e.g. toothache, neuralgia, migraine)
• Treatment or medication use for headache or bruxism in the last 2 years
• Local skin infection over the masseter or temporal muscle