Effect of Polyphenol-rich Cocoa Products on Cognitive Function

Consumption of Polyphenol Rich Cocoa Products Over 8 Weeks and Its Effect on Cognitive Function in Individuals in Their 5th Decade of Life.

This project aims to investigate whether consumption of cocoa polyphenols has an impact on cognitive function in individuals aged 50 to 60 years of age and if such an improvement is a result of an improvement in risk factors associated with cognitive decline in ageing.

Healthy cognitive ageing is an important aspect of the ageing process as it involves larger numbers of people compared to those who have already been diagnosed with conditions on the dementia spectrum (Deary et al, 2009). Hence, an active effort looking at potential lifestyle factor modification interventions to help maintain cognitive well-being are warranted.

With an ageing population, the prevalence of cognitive syndromes such as Alzheimer's disease and Parkinson's disease increases (Vauzour, 2012). Nutritional interventions can play a role in successful ageing by helping to delay the onset of age-related conditions (Hendrickx, McEwen & van der Ouderaa, 2005; Brown, Riby & Reay, 2009; Monti, Moulton & Cohen, 2015). Studies have investigated the potential role of polyphenols as part of a neuroprotective lifestyle. Mouse model studies have looked at varying polyphenol sources such as tea (Haque et al., 2006; Kaur et al., 2008), blueberry (Shukitt-Hale et al., 2015; Williams et al., 2008), Gingko Biloba (Shif et al., 2008) and cocoa (Bisson et al., 2008) to mention a few.

Ageing and neurodegenerative diseases are caused by neuronal death which in turn can be triggered by neurotoxins, neuroinflammation and specific genetic mutations (Bishop, Lu & Yankner, 2010). Dietary polyphenols have been observed to provide neuroprotection against cellular alteration by modulating the neuronal function against endogenous neurotoxins and inhibition of glial induced neuroinflammation (Vauzour, 2012).

Inclusion Criteria:

• Males & Females aged 50-60years of age with normal or corrected to normal vision
• BMI cut off points of ≥18.5 to ≤29.9 kg/m2
• Waist circumference smaller than 102cm for males & smaller than 88cm for women
• Blood pressure of ≥ 90 over 60 and ≤ 120 over 80
• MoCA test score ≥ 26

Exclusion Criteria:

• Allergies to cocoa or any other ingredients commonly found in cocoa confectionary eg: milk, nuts, soya
• Smoker
• Women who are new or expecting mothers, maybe or are currently pregnant and/or breastfeeding
• Taking medications for chronic conditions including (but not limited to) diabetes, heart disease, hypertension
• No previous history of stroke, brain trauma and other head-related injuries
• No diagnosis of depression and/or anxiety
• No previous cancer diagnosis
• Taking antibiotics
• Taking steroids and non-steroidal anti-inflammatory drugs (NSAIDS)
• Women on Hormone Replacement Therapy (HRT)
• Taking medication that can cause drowsiness or affect cognitive functioning
• Taking polyphenol supplements including (but not limited to) green tea extract, acai berry extract
• Taking soy/a supplements
• History of alcohol misuse
• Fear of needles and/or fainting when blood is taken