Due to the difficulty in meeting the selection criteria by preventing continued recruitment to the trial. This has made recruitment more difficult and has prolonged the recruitment time to more than two years from the initially planned end of study

Assisted reproduction patients candidates to an IVF/ICSI cycle with low follicular reserve: after at least one cycle of stimulation obtaining 0-4 oocytes.

Improve the follicular response in patients with low response, increasing the number of follicles in subsequent cycles to treatment with growth factors.

Inclusion Criteria:

1. Patients must give written consent.

2. To be a healthy woman acting voluntarily, aged 18 to 42 years (both inclusive) at the time of study selection time of selection for the study.

3. Have a BMI ≥ 18 kg/m2 and ≤ 35 kg/m2

4. Patients with low ovarian reserve (AMH <1.1 ng/mL) according to the Bologna criteria.

5. Patients who are going to undergo IVF/ICSI cycle with low follicular response: who after a previous cycle of stimulation have obtained 0-3 or more follicular 0-3 oocytes have been obtained after a previous stimulation cycle; or if 0-3 oocytes are expected to be obtained at the present time (less than 4 follicles).

   oocytes (less than 4 follicles in the basal ultrasound).

6. To have recent analytical results (haemogram, biochemistry and coagulation); at least 11 months prior to inclusion in the study and a serology, according to clinical practice.

Translated with www.DeepL.com/Translator (free version)