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| Name | Class |
|---|---|
| Heilongjiang University of Chinese Medicine | OTHER |
The aim of this study is to confirm the TCM syndrome types and TCM constitution classifications of the patients with intestinal polyps via on-site epidemiological survey, to analyze metabolomics of the serum samples of intestinal polyps and healthy volunteers, and to study the metabolomics differences of the two populations and the metabolomics variations of the patients with intestinal polyps of pre-polypectomy and post-polypectomy. Finally, this study is to investigate the serum metabolomics variations of patients with intestinal polyps of pre-polypectomy and post-polypectomy and the relationship with their TCM syndrome types and TCM constitution classifications, to determine the correlation among pathology, TCM constitution, TCM syndrome types and the metabonomics variations of patients with intestinal polyps.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intestinal Polyps | The patients who were diagnosed with Intestinal Polyps. |
| |
| Normal colonoscopy | People who were diagnosed by colonoscopy without intestinal polyps. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Aiming to obtain biomarker groups of different pathological types of intestinal polyps, The potential biomarkers will be entered KEGG database to obtain metabolic pathways. | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| All data matrices are introduced to Ezinfo software for PCA and OPLS-DA. Using improved "MetPA enriched pathways" method to discover the metabolic pathways of the disease. | 3 days |
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Inclusion Criteria:
Exclusion Criteria:
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Intestinal polyps patients
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| Name | Affiliation | Role |
|---|---|---|
| Wei Xu, Doctor | First Affiliated Hospital of Harbin Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital of Harbin Medical University | Harbin | Heilongjiang | 150001 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31784934 | Derived | Du WZ, Zhang AH, Ren JL, Lyu K, Tuo LY, Xu W. Study of Differential Serum Metabolites in Patients with Adenomatous Polyps of Colon and Yang-Deficiency Constitution Based on Ultra-Performance Liquid Chromatography-Mass Spectrometry. Chin J Integr Med. 2022 May;28(5):403-409. doi: 10.1007/s11655-019-3181-9. Epub 2019 Nov 29. |
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| ID | Term |
|---|---|
| D007417 | Intestinal Polyps |
| ID | Term |
|---|---|
| D011127 | Polyps |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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serum