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Dystonia is increasingly being considered as a multi-nodal network disorder involving both basal ganglia and cerebellar dysfunction. The aim of this study is to determine if "Multi-Target" Thalamic and Pallidal Deep Brain Stimulation improves hemi-dystonia patients who are receiving inadequate therapy from GPi DBS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pallidal (GPi) Deep Brain Stimulation | Active Comparator | GPi is the standard target for treating most dystonia. This setting will be the active comparator |
|
| Thalamic (Vim) Deep Brain Stimulation | Experimental | Vim is the standard target to treat cerebellar dysfunction in movement disorders. It is not routinely used in secondary dystonia |
|
| GPi + Vim (Multi-Target) Deep Brain Stimulation | Experimental | Combined stimulation of GPi and Vim stimulation (both electrodes ON) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Deep Brain Stimulation | Device | Deep Brain Stimulation Electrode |
|
| Measure | Description | Time Frame |
|---|---|---|
| Burke Fahn Marsden Disability Rating Scale (BFMDRS) | 3 months | |
| SF-36 Quality of Life Scale | 3 months | |
| Adverse effects of Vim or Vim + GPi Neuromodulation | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chris Honey, MD,DPhil,FRCSC | Contact | 604-875-5894 | chris.honey@telus.net | |
| Leah Polyhronopoulos, BSc | Contact | 778-938-6127 | leahpoly@mail.ubc.ca |
| Name | Affiliation | Role |
|---|---|---|
| Chris Honey, MD,DPhil,FRCSC | University of British Columbia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Vancouver General Hospital | Recruiting | Vancouver | British Columbia | V5Z 1M9 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26241157 | Background | Slotty PJ, Poologaindran A, Honey CR. A prospective, randomized, blinded assessment of multitarget thalamic and pallidal deep brain stimulation in a case of hemidystonia. Clin Neurol Neurosurg. 2015 Nov;138:16-9. doi: 10.1016/j.clineuro.2015.07.012. Epub 2015 Jul 29. | |
| 24333801 | Background | Prudente CN, Hess EJ, Jinnah HA. Dystonia as a network disorder: what is the role of the cerebellum? Neuroscience. 2014 Feb 28;260:23-35. doi: 10.1016/j.neuroscience.2013.11.062. Epub 2013 Dec 11. |
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| ID | Term |
|---|---|
| D004421 | Dystonia |
| D020821 | Dystonic Disorders |
| ID | Term |
|---|---|
| D020820 | Dyskinesias |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D046690 | Deep Brain Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D013514 | Surgical Procedures, Operative |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D009069 | Movement Disorders |
| D002493 | Central Nervous System Diseases |