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| Name | Class |
|---|---|
| Canadian Institutes of Health Research (CIHR) | OTHER_GOV |
| Calgary Health Region | OTHER |
| Medtronic | INDUSTRY |
The purposes of this study are:
Deep brain stimulation (DBS) of the globus pallidus has been proposed as a treatment for cervical dystonia. At present there are only anecdotal reports of benefit. The objective of this project is to prospectively assess the outcomes of DBS on cervical dystonia in a blinded manner. Our hypothesis is that in patients refractory to medical management, bilateral pallidal DBS will reduce the severity of cervical dystonia at 1 year follow up.
The research plan is that of a feasibility study, examining outcomes of 10 patients who would be referred for surgical management due to the severity of their disease. The Toronto Western Spasmodic Torticollis Rating Scale (TWSTR) will be preformed by a blinded neurologist at the completion of the trial.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Deep brain stimulation | Device |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in neck postures/movements | ||
| Improvement in quality of life |
| Measure | Description | Time Frame |
|---|---|---|
| Document adverse effects of surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Zelma Kiss, MD | University of Calgary | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dr. Zelma Kiss | Calgary | Alberta | T2N 4N1 | Canada | ||
| Dr. Matt Wheatley |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17905796 | Derived | Kiss ZH, Doig-Beyaert K, Eliasziw M, Tsui J, Haffenden A, Suchowersky O; Functional and Stereotactic Section of the Canadian Neurosurgical Society; Canadian Movement Disorders Group. The Canadian multicentre study of deep brain stimulation for cervical dystonia. Brain. 2007 Nov;130(Pt 11):2879-86. doi: 10.1093/brain/awm229. Epub 2007 Sep 28. |
| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D014103 | Torticollis |
| ID | Term |
|---|---|
| D004421 | Dystonia |
| D020820 | Dyskinesias |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D046690 | Deep Brain Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D013514 | Surgical Procedures, Operative |
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| Edmonton |
| Alberta |
| T2G 2B7 |
| Canada |
| Dr. Chris Honey | Vancouver | British Columbia | V5Z 4E5 | Canada |
| Dr. Jerry Krcek | Winnipeg | Manitoba | R3C 0N2 | Canada |
| Dr. Andrew Parrent | London | Ontario | N6A 5A5 | Canada |
| D013568 |
| Pathological Conditions, Signs and Symptoms |