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| Name | Class |
|---|---|
| Bezmialem Vakif University | OTHER |
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The aim of this study is to measure of the parathyroid cell viability and the the amount of calcium sensing receptor of the parathyroid cells which were placed into a new transportation solution (BAVU solution) for parathyroid allotransplantation.
The cold ischemia of organs, has harmful effects on the tissues due to oxidative stress and inflammation. This is physiopathologically defined as ischaemia/re-perfusion injury (IRI) in organ transplantation. Parathyroid allotransplantation has an increased popularity at the last decade. But the cold ischemia due to transportation of the transplant tissue is a very important problem.
Calcium sensing receptor plays a crucial role in regulating Parathormone secretion which means controlling of the calcium-dependent systemic ion homeostasis.
The investigators developed a new tissue transporting solution for parathyroid allotransplantation and the investigators measured the parathyroid cell viability and the the amount of calcium sensing receptor of the parathyroid cells at the 0., 6., 12. and 24. hours of the parathyroid cells which were placed into our new solution.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| BAVU Solution 0. hour (control) | No Intervention | Viability, Calcium sensing receptor and parathormone levels of Parathyroid cells at 0. hour | |
| BAVU Solution 6. hour | Experimental | Viability, Calcium sensing receptor and parathormone levels of Parathyroid cells at 6. hour |
|
| BAVU Solution 12. hour | Experimental | Viability, Calcium sensing receptor and parathormone levels of Parathyroid cells at 12. hour |
|
| BAVU Solution 18. hour | Experimental | Viability, Calcium sensing receptor and parathormone levels of Parathyroid cells at 18. hour |
|
| BAVU Solution 24. hour | Experimental | Viability, Calcium sensing receptor and parathormone levels of Parathyroid cells at 24. hour |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| BAVU Solution | Drug | Tissue preservation solution for transplantation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cell viability of Parathyroid cells | The investigators will measure the viability of Parathyroid cells at 0 hour at the BAVU solution | 0 hour |
| Cell viability of Parathyroid cells | The investigators will measure the viability of Parathyroid cells at 6 hours at the BAVU solution | 6 hours |
| Cell viability of Parathyroid cells | The investigators will measure the viability of Parathyroid cells at 12 hours at the BAVU solution | 12 hours |
| Cell viability of Parathyroid cells | The investigators will measure the viability of Parathyroid cells at 18 hours at the BAVU solution | 18 hours |
| Cell viability of Parathyroid cells | The investigators will measure the viability of Parathyroid cells at 24 hours at the BAVU solution | 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Erhan Aysan, Prof. M.D. | Contact | +905322034879 | erhanaysan@hotmail.com | |
| Ufuk Oguz Idiz, M.D. | Contact | +905062044714 | oguzidiz@hotmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bezmialem University | Recruiting | Istanbul | 34093 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21566713 | Result | Guibert EE, Petrenko AY, Balaban CL, Somov AY, Rodriguez JV, Fuller BJ. Organ Preservation: Current Concepts and New Strategies for the Next Decade. Transfus Med Hemother. 2011;38(2):125-142. doi: 10.1159/000327033. Epub 2011 Mar 21. | |
| 20374733 | Result | Hendy GN, Guarnieri V, Canaff L. Calcium-sensing receptor and associated diseases. Prog Mol Biol Transl Sci. 2009;89:31-95. doi: 10.1016/S1877-1173(09)89003-0. Epub 2009 Oct 7. |
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| 24311404 | Result | Voigt MR, DeLario GT. Perspectives on abdominal organ preservation solutions: a comparative literature review. Prog Transplant. 2013 Dec;23(4):383-91. doi: 10.7182/pit2013100. |
| 17414706 | Result | Nawrot I, Wozniewicz B, Tolloczko T, Sawicki A, Gorski A, Chudzinski W, Wojtaszek M, Grzesiuk W, Sladowski D, Karwacki J, Zawitkowska T, Szmidt J. Allotransplantation of cultured parathyroid progenitor cells without immunosuppression: clinical results. Transplantation. 2007 Mar 27;83(6):734-40. doi: 10.1097/01.tp.0000258601.17505.9d. |