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The functional parathyroid auto-transplantation (PA) could release parathyroid hormone (PTH) into the circulatory system of the body through the capillaries. But when parathyroid glands were auto-grafted in the sternocleidomastoid muscle, it would be inconvenient to detect PTH to examine whether the graft functions. So the investigators took the forearm as the aim place for auto-transplantation, either subcutaneous or brachioradialis, with its relatively fixed - antecubital vein blood test which is simple. The survival criteria is assumed as the PTH gradient of 1.5 times or greater through comparing the bilateral PTH value in grafted and not-grafted forearm.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| new site for parathyroid auto-graft | Experimental | choose the site fairly close to the antecubital vein for parathyroid auto-transplantation |
|
| traditional parathyroid autograft | Active Comparator | choose not intensely close to antecubital vein for parathyroid auto-transplantation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| injection with a syringe in new-site for parathyroid autografting | Procedure | new-site for parathyroid autografting, close to the antecubital vein |
|
| Measure | Description | Time Frame |
|---|---|---|
| parahthyroid hormone gradient by comparing between grafted and non-grafted forearm | The survival criteria is that the gradient of parathyroid hormone reaches 1.5 time or greater by comparing between grafted and non-grafted forearm | 1 months, 3 months and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| hypoparathyroidism: parathyroid hormone less than 15pg/ml(range from 15 to 65pg/ml) | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gaosong Wu, PhD | Contact | 0086-138-7144-4606 | wugaosongtj@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Gaosong Wu, PhD | Department of Thyroid and Breast Surgery Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tongji Hospital | Recruiting | Wuhan | Hubei | 430030 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30704522 | Derived | Cui Q, Kong D, Li Z, Wang K, Zhang D, Tang J, Liao X, Yuan Q, Gong Y, Wu G. Parathyroid autotransplantation at a novel site for better evaluation of the grafted gland function: study protocol for a prospective, randomized controlled trial. Trials. 2019 Jan 31;20(1):96. doi: 10.1186/s13063-019-3195-9. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Apr 16, 2017 | |
| Reset | Jun 30, 2017 | |
| Release | Jul 6, 2017 |
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|
| injection with a syringe in traditional site for parathyroid autografting | Procedure | traditional-site for parathyroid autografting,not intensively close to the antecubital vein |
|
| Unrelease | Yes |
| Release | Oct 14, 2017 |
| Reset | Dec 13, 2017 |
| Release | Apr 24, 2018 |
| Unrelease | Oct 20, 2018 |
| Release | Apr 9, 2019 |
| Reset | Jul 2, 2019 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Apr 16, 2017 | Jun 30, 2017 | |||
| Jul 6, 2017 | Yes | |||
| Oct 14, 2017 | Dec 13, 2017 | |||
| Apr 24, 2018 | Oct 20, 2018 | |||
| Apr 9, 2019 | Jul 2, 2019 |
| ID | Term |
|---|---|
| D007011 | Hypoparathyroidism |
| ID | Term |
|---|---|
| D010279 | Parathyroid Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D007267 | Injections |
| ID | Term |
|---|---|
| D004333 | Drug Administration Routes |
| D004358 | Drug Therapy |
| D013812 | Therapeutics |
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