Natural Killer Cells Reconstitution Kinetics Post Haploidentical Transplantation

Natural Killer Cells Reconstitution Kinetics Post T Cells Repleted Haploidentical Transplantation

Patients undergoing haploidentical allo-HSCT will be prospectively enrolled exploring the NK cells phenotype and functional reconstitution.

Patients with hematological malignancies suitable for allo-HSCT but without HLA-identical related or unrelated donors were candidates for the HLA-haploidentical HSCT. Patients undergoing haploidentical allo-HSCT will be prospectively enrolled exploring the NK cells phenotype and functional reconstitution. Peripheral blood will be collected by day15, 30, 60, 90, 180, and 1 year post transplantation.

Inclusion Criteria:

• AML or MDS or CML or ALL undergoing haploidentical stem cells transplantation

Exclusion Criteria:

• NR or refractory AML/ALL before transplantation donors from mother or collateral related