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This research will confirm that Pcv-aCO2 is suitable for the guidance of early fluid therapy and the evaluation of the prognosis of patients with abnormal hemodynamics after abdominal tumor surgery, and is expected to be a new monitoring index to improve the therapeutic effect of these patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| standard group | Active Comparator | The patients with ScvO2 ≥ 70% will receive the conventional fluid therapy.than collect the data of ScvO2 and Pcv-aCO2: ScvO2≥70%，and furthermore, Pcv-aCO2 is divided into "≤6mmHg" and ">6mmHg" |
|
| control group | Sham Comparator | The patients with ScvO2 <70% will receive the standardized fluid therapy for 6 hours.than collect the data of ScvO2 and Pcv-aCO2: ScvO2<70%，and furthermore, Pcv-aCO2 is divided into "≤6mmHg" and ">6mmHg" |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| standardized fluid therapy | Other | The patients with ScvO2 <70% will receive the standardized fluid therapy for 6 hours. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The change of Pcv-aCO2 | The change of Pcv-aCO2 (mmHg) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively. | fluid resuscitation for 6 hours, 12 hours and 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| The treatment success rate in different groups | Collect the index of treatment success rate(%) of patients in different groups. | Twenty-eighth days after admission |
| The 28 day mortality in different groups |
| Measure | Description | Time Frame |
|---|---|---|
| The change of Central Venous Oxygen Saturation (ScvO2) | The change of Central venous oxygen saturation (ScvO2, %)after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively. | fluid resuscitation for 6 hours, 12 hours and 24 hours |
| The change of hemoglobin (Hb) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yang Yang, physician | Contact | 022-23340123 | 1021 | yyicu3021@126.com |
| Yang Lu, physician | Contact | 022-23340123 | 1021 | Yang_lu1299@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Wanhua Wang, director | Tianjin Medical University Cancer Institute and Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tianjin Medical University Cancer Institute and Hospital | Recruiting | Tianjin | Tianjin Municipality | 300060 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21034476 | Background | Futier E, Robin E, Jabaudon M, Guerin R, Petit A, Bazin JE, Constantin JM, Vallet B. Central venous O(2) saturation and venous-to-arterial CO(2) difference as complementary tools for goal-directed therapy during high-risk surgery. Crit Care. 2010;14(5):R193. doi: 10.1186/cc9310. Epub 2010 Oct 29. | |
| 20179283 | Background |
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| ID | Term |
|---|---|
| D000008 | Abdominal Neoplasms |
| D059413 | Intraabdominal Infections |
| D009369 | Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D007239 | Infections |
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| conventional fluid therapy | Other | The patients with ScvO2 ≥ 70% will receive the conventional fluid therapy. |
|
Collect the index of 28 day mortality(%) of patients in different groups.
| Twenty-eighth days after admission |
| The hospitalization course in different groups | Collect the index of hospitalization course(days) of patients in different groups. | Twenty-eighth days after admission |
The change of hemoglobin (Hb, g/L) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively. |
| fluid resuscitation for 6 hours, 12 hours and 24 hours |
| The change of blood lactic acid (Lac) | The change of blood lactic acid (Lac, mmol/L) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively. | fluid resuscitation for 6 hours, 12 hours and 24 hours |
| The change of Cardiac Index (CI) | The change of Cardiac Index (CI, L/(min•m^2)) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively. | fluid resuscitation for 6 hours, 12 hours and 24 hours |
| The Oxygen Supply status (DO2) in different groups | Collect the index of oxygen supply (DO2, ml/(min•m^2)) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively. | fluid resuscitation for 6 hours, 12 hours and 24 hours |
| The Oxygen Consumption (VO2) in different groups | Collect the index of oxygen consumption (VO2, ml/(min•m^2)) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively. | fluid resuscitation for 6 hours, 12 hours and 24 hours |
| Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA; Emergency Medicine Shock Research Network (EMShockNet) Investigators. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA. 2010 Feb 24;303(8):739-46. doi: 10.1001/jama.2010.158. |
| 19854541 | Background | Pope JV, Jones AE, Gaieski DF, Arnold RC, Trzeciak S, Shapiro NI; Emergency Medicine Shock Research Network (EMShockNet) Investigators. Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis. Ann Emerg Med. 2010 Jan;55(1):40-46.e1. doi: 10.1016/j.annemergmed.2009.08.014. Epub 2009 Oct 25. |
| 21078769 | Background | Harilall Y, Adam JK, Biccard BM, Reddi A. Correlation between cerebral tissue and central venous oxygen saturation during off-pump coronary bypass graft surgery. Perfusion. 2011 Mar;26(2):83-90. doi: 10.1177/0267659110387846. Epub 2010 Nov 15. |