The Interest of the Xylocaine® and Ketamine on the Management of Acute and Chronic Ain After Colectomy by Laparoscopy

The Interest of the Xylocaine® and Ketamine on the Per and Postoperative Management of Acute and Chronic Postoperative Pain After Colectomy by Laparoscopy

Recent clinical studies in abdominal surgery have shown that the use of Xylocaine® parenterally intraoperative at plasma concentrations below the toxic threshold of 5 .mu.g / ml, had an analgesic effect and decreased postoperative morphine consumption.

This study aims to evaluate the activity of Xylocaine® and ketamine separately administered parenterally, in terms of postoperative morphine consumption and decrease incidences of postoperative chronic pain at 3 and 6 months after laparoscopic colectomy compared the placebo group.

The evaluation of the intensity of postoperative pain, hyperalgesia perished skin surface scarring) and pain perception threshold by Pain Matcher® confirm or not the predictive nature of these criteria in the occurrence of chronic pain.

Inclusion Criteria:

• Surgery: segmental or total colectomy performed by laparoscopy
• Anesthesia state 1 and 3

Exclusion Criteria:

• Patients classified Anesthesia state 4 or 5
• Allergy or intolerance to any of the products used in the protocol
• Creatinine clearance calculated by the Cockcroft formula below 50 ml / min
• Hepatocellular insufficiency
• Severe heart failure
• Peptic ulcer
• Chronic inflammatory bowel disease (IBD)
• Previous history of epilepsy or seizures
• Surgery emergency, palliative surgery, revision surgery
• Chronic pain requiring regular intake of analgesics include opioids
• Patients treated with lidocaine patch
• Psychic Disorder
• Additive Conduct vis-à-vis alcohol or mind-altering substances
• Pregnant or breastfeeding women