A Trial to Assess the Pain-control Efficacy of Intra-articular Toradol Compared to Oral NSAIDs

A Randomized Controlled Trial to Assess the Pain-control Efficacy of Intra-articular Toradol Compared to Oral NSAIDs: A Pilot Study

The study objective is to determine whether a single intra-articular dose of an anti-inflammatory (Toradol) will reduce the need for other analgesic medications and, if so, how long the benefits will last.

Inclusion Criteria:

• Patients with radiographic evidence of osteoarthritis (OA) who present to the ED with a chief complaint of knee pain that the treating provider attributes to their arthritis.

Exclusion Criteria:

• Acute knee trauma
• Intra-articular steroid injection within 6 months
• History of gout or rheumatoid arthritis
• X ray evidence of pathologic fracture, malignancy, or other non-OA cause of symptoms
• Signs or symptoms or high risk of acute infection: Recent fevers and chills; Erythema, warmth, or pain out of proportion to exam; History of hemodialysis; History of IV drug use
• Lidocaine allergy
• Any contraindication to NSAID therapy, including: Allergy; Pregnancy; History of renal insufficiency; History of gastritis, GERD or GI bleeding; Primary care physician's restriction of its use
• Contraindication to the procedure, including: Hemophilia; History of total knee replacement of the affected joint
• An inability to give informed consent; Active psychosis; Diminished capacity requiring another person to provide consent for medical treatment
• An inability to be contacted for follow-up