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The investigators aim to evaluate the acute effects of potassium supplementation achieved by ingestion of potassium rich food, on vascular health.
Many studies have shown that an increase in potassium through the diet or through potassium pills helps to lower blood pressure. Also, the amount of oral potassium taken can improve how well the participants blood vessels work. These studies have focused on potassium given in the form of a pill. The investigators are interested in the effect of potassium consumed through food sources and how it will effect arterial health and blood pressure. The world health organization (WHO) recommends a K⁺ intake of at least 3510 mg/day from food for adults, excluding those with impaired K⁺ excretion. In this study the investigators aim to provide approximately 75% (approximately 2000 mg) of the total daily recommended intake for potassium in one meal. The investigators do not know whether dietary potassium (not pill form) will acutely improve the arterial health and if it will cause a decrease in blood pressure. The investigators hypothesis to see an improvement in vascular function following a high potassium meal compared to a low potassium meal.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High potassium meal | Experimental | In this arm individuals will be provided with a breakfast meal that provides ~2400 mg of dietary potassium. |
|
| Low potassium meal | Active Comparator | In this arm individuals will be provided with a breakfast meal that provides ~540 mg of dietary potassium. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High Potassium Meal | Other | Breakfast meal that provides ~2400 mg of dietary potassium. Meals are isocaloric. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Flow Mediated Dilatation | Flow Mediated Dilatation is a method used to measure endothelial-dependent regulation of conduit artery tone(Joannides R, 1995). | Flow Mediated Dilatation will be assessed over 2 clinic visits, at 3 times points with in each visit; pre-prandial and post-prandial at 60 min and 120 min |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mount Sinai Hospital | Toronto | Ontario | M5G 1X5 | Canada |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| Low Potassium Meal | Other | Breakfast meal that provides ~540 mg of potassium. Meals are isocaloric. |
|