Postprandial Effects of a High Potassium Meal

Postprandial Physiological Effects of a High Potassium Meal in Patients With Hypertension

The investigators aim to evaluate the acute effects of potassium supplementation achieved by ingestion of potassium rich food, on vascular health.

Many studies have shown that an increase in potassium through the diet or through potassium pills helps to lower blood pressure. Also, the amount of oral potassium taken can improve how well the participants blood vessels work. These studies have focused on potassium given in the form of a pill. The investigators are interested in the effect of potassium consumed through food sources and how it will effect arterial health and blood pressure. The world health organization (WHO) recommends a K⁺ intake of at least 3510 mg/day from food for adults, excluding those with impaired K⁺ excretion. In this study the investigators aim to provide approximately 75% (approximately 2000 mg) of the total daily recommended intake for potassium in one meal. The investigators do not know whether dietary potassium (not pill form) will acutely improve the arterial health and if it will cause a decrease in blood pressure. The investigators hypothesis to see an improvement in vascular function following a high potassium meal compared to a low potassium meal.

Inclusion Criteria:

• 18-80 years
• Normal sinus rhythm
• A diagnosis of hypertension on medical therapy with an ambulatory systolic blood pressure <160 mmHg and diastolic blood pressure <90 mmHg, or a diagnosis of stable coronary artery disease

Exclusion Criteria:

• Recent hospital admission due to an cardiovascular events
• Serum K+ concentration >5.0 mmol/L
• Current smoking
• Women who are pregnant
• Diabetic patients - patients receiving insulin therapy
• Glomerular filtration rate < 90mls/min/1.73m2
• On loop diuretic therapy
• Food allergies and/or intolerance to meal items