Effect of Ghrelin on Glucose Metabolism After Bariatric Surgery

Effect of Ghrelin on Glucose Metabolism After Bariatric Surgery

The purpose of this study is to determine if the altered nutrient exposure to the GI tract after bariatric surgery reveals a negative incretin effect of ghrelin.

Inclusion Criteria:

• BMI ≥ 35 kg/m2
• Age 21-65 years
• Weight ≤ 200 kg

Exclusion Criteria:

• Type 2 or Type 1 diabetes
• Medications that alter insulin sensitivity or carbohydrate metabolism
• Positive pregnancy test
• Known history of intestinal diseases including, but not limited to, inflammatory bowel disease (e.g. Chronic Ulcerative Colitis, Crohn's disease, celiac sprue)
• Prior gastric or intestinal surgery or pancreas resection
• History of cardiovascular disease, including but not limited to: myocardial infarction, angioplasty, arrhythmia, uncontrolled hypertension
• History of chronic kidney disease or renal insufficiency; creatinine > 1.8 mg/dl.
• History of chronic liver disease, including but not limited to: cirrhosis, hepatitis, portal hypertension; AST and/or ALT > 2x the upper limit of normal.
• Abnormal ECG