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The effects and safety of Human cord blood mononuclear cell for delayed encephalopathy after carbon monoxide poisoning
To evaluate the effect and mechanism of human cord blood mononuclear cell transplantation for delayed encephalopathy after carbon monoxide poisoning
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| intervention group | Experimental | Human Cord Blood Mononuclear Cell will be slowly infusion three times,at one days, 30 days,at 60days. |
|
| control group | Placebo Comparator | hyperbaric oxygen |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Human cord blood mononuclear cell | Biological | The patients were treated by human cord blood mononuclear cell through subarachnoid space |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change From Baseline in Mini-Mental State Examination (MMSE) | Baseline, 4, 8, 12 and 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Chang from baseline in head CT | Baseline, 6 and 12 months | |
| Cerebrospinal levels of IL-2,IL-4,IL-6,IL-10,TNF,IFN-γ，IL-17A，IL-8，IL-12p70，MIG，MCP-1(ng/ul) | Baseline, 1 and 2 months | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shaoda Ren, Ph.D. | Contact | 86-0635-8272202 | zslrsd@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Shuangfeng Chen, Ph.D. | Liaocheng People's Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Liaocheng city people's hospital | Recruiting | Liaocheng | Shandong | 0635 | China |
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| ID | Term |
|---|---|
| D002249 | Carbon Monoxide Poisoning |
| ID | Term |
|---|---|
| D005739 | Gas Poisoning |
| D011041 | Poisoning |
| D064419 | Chemically-Induced Disorders |
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| ID | Term |
|---|---|
| D006931 | Hyperbaric Oxygenation |
| ID | Term |
|---|---|
| D010102 | Oxygen Inhalation Therapy |
| D012138 | Respiratory Therapy |
| D013812 | Therapeutics |
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| hyperbaric oxygen | Other | The patients were treated by hyperbaric oxygen |
|
| Serum levels of IL-2,IL-4,IL-6,IL-10,TNF,IFN-γ，IL-17A，IL-8，IL-12p70，MIG，MCP-1(ng/ul) |
| Baseline,1 and 2 months |
| Change From Baseline in Activities of Daily Living (ADL) | Baseline, 4, 8, 12 and 24 weeks |