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The purpose of this study is to access the clinical characteristics and risk factors for neurological sequelae after acute carbon monoxide poisoning.
After being informed about the study and potential risks, patients meet the inclusion criteria would be given informed consent and entry the study. The data will be collected according to self-designed questionnaire, including :1) The baseline characteristics: would be recorded 6 hours after patients presentation;2) Patients' self evaluation for discomfort symptoms: would be recorded at day 0, week 1, 3 and 6, month 6 and 12ï¼›3) Neurological function: would be recorded at day 0, week 6, month 6 and 12.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Non-NS ( Non-neurological sequelae) group | Patients who do not develop neurological dysfunction after acute carbon monoxide poisoning |
| |
| NS (Neurological sequelae) group | Patients who develop neurological dysfunction after acute carbon monoxide poisoning |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other | No intervention will be given |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes of Mini-mental State Examination (MMSE) score at 6 weeks | Score ranges from 0 to 30, a lower score means a worse outcome. | Changes of score from baseline to 6 weeks |
| Changes of Mini-mental State Examination (MMSE) score at 6 months | Score ranges from 0 to 30, a lower score means a worse outcome. | Changes of score from baseline to 6 months |
| Changes of Mini-mental State Examination (MMSE) score at 12 months | Score ranges from 0 to 30, a lower score means a worse outcome. | Changes of score from baseline to 12 months |
| Changes of Montreal cognitive assessment (MoCA）score at 6 weeks | Score ranges from 0 to 30, a lower score means a worse outcome. | Changes of score from baseline to 6 weeks |
| Changes of Montreal cognitive assessment (MoCA）score at 6 months | Score ranges from 0 to 30, a lower score means a worse outcome. | Changes of score from baseline to 6 months |
| Changes of Montreal cognitive assessment (MoCA）score at 12 months | Score ranges from 0 to 30, a lower score means a worse outcome. | Changes of score from baseline to 12 months |
| Changes of Hamilton Depression Scale(HAMD) score at 6 weeks | Score ranges from 0 to 54, a higher score means a worse outcome. |
| Measure | Description | Time Frame |
|---|---|---|
| Rates of cardiovascular and cerebrovascular events | Cardiovascular and cerebrovascular events includes：cardiac arrest, myocardial infarction, cerebral hemorrhage, and cerebral infarction. A patient develops any of the former diseases during following up would be record as 1 event. | through study completion, an average of 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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All the patients with acute carbon monoxide poisoning would be recruited from the First Hospital of Jilin University.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ning Dong, M.D. | Contact | +8615804301769 | dnjl2007@jlu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Li Pang, M.D. | The First Hospital of Jilin University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| First Hospital of Jilin University | Changchun | Jilin | 130000 | China |
The IPD would be shared with other researcher through e-mail contact with Ning Dong (dnjl2007@jlu.edu.cn)
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| ID | Term |
|---|---|
| D002249 | Carbon Monoxide Poisoning |
| ID | Term |
|---|---|
| D005739 | Gas Poisoning |
| D011041 | Poisoning |
| D064419 | Chemically-Induced Disorders |
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blood serum
| Changes of score from baseline to 6 weeks |
| Changes of Hamilton Depression Scale(HAMD) score at 6 months | Score ranges from 0 to 54, a higher score means a worse outcome. | Changes of score from baseline to 6 months |
| Changes of Hamilton Depression Scale(HAMD) score at 12 months | Score ranges from 0 to 54, a higher score means a worse outcome. | Changes of score from baseline to 12 months |
| Changes of Hamilton Anxiety Scale (HAMA) score at 6 weeks | Score ranges from 0 to 56, a higher score means a worse outcome. | Changes of score from baseline to 6 weeks |
| Changes of Hamilton Anxiety Scale (HAMA) score at 6 months | Score ranges from 0 to 56, a higher score means a worse outcome. | Changes of score from baseline to 6 months |
| Changes of Hamilton Anxiety Scale (HAMA) score at 12 months | Score ranges from 0 to 56, a higher score means a worse outcome. | Changes of score from baseline to 12 months |
| Changes of Activity of Daily Living (ADL) score at 6 weeks | Score ranges from 0 to 80, a higher score means a worse outcome. | Changes of score from baseline to 6 weeks |
| Changes of Activity of Daily Living (ADL) score at 6 months | Score ranges from 0 to 80, a higher score means a worse outcome. | Changes of score from baseline to 6 months |
| Changes of Activity of Daily Living (ADL) score at 12 months | Score ranges from 0 to 80, a higher score means a worse outcome. | Changes of score from baseline to 12 months |
| Changes of self-evaluation of discomfort symptoms scale at 1 week | This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome | Changes of score from baseline to 1 week |
| Changes of self-evaluation of discomfort symptoms scale at 3 weeks | This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome | Changes of score from baseline to 3 weeks |
| Changes of self-evaluation of discomfort symptoms scale at 6 weeks | This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome | Changes of score from baseline to 6 weeks |
| Changes of self-evaluation of discomfort symptoms scale at 6 months | This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome | Changes of score from baseline to 6 months |
| Changes of self-evaluation of discomfort symptoms scale at 12 months | This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome | Changes of score from baseline to 12 months |
| Rates of accidental injury |
Accidental injuries may include accidental fall, fracture, traffic accident etc. A patient develops any of the former during following up would be record as 1 event. |
| through study completion, an average of 1 year |