Identification of Markers (Klotho-FGF23 Axis) as Determinant in the Evolution of Arterial Stiffness During the First Year of Renal Transplant

Identification of Markers (Klotho-FGF23 Axis) as Determinant in the Evolution of Arterial Stiffness During the First Year of Renal Transplant

The primary objective is to show that the contribution of Klotho by the renal graft is an independent determinant of the evolution of the recipient's central arterial stiffness during the first year of renal transplant. The contribution of Klotho by the graft will be estimated by: its circulating concentrations assay, its urinary excretion assay, and, indirectly, by the circulating concentrations of FGF23. The recipient's central arterial stiffness will be estimated by the measure of the carotid-femoral pulse wave velocity, noninvasive reference method for measuring aortic stiffness in human.

Inclusion Criteria:

• Man or woman 18 to 70 years old
• Renal transplant
• Dead donor or alive donor
• Immunosuppression including a calcineurin inhibitor
• Written consent

Exclusion Criteria:

• MultipleTransplant
• Morbid Obesity (Body Mass Index (BMI)> 40 kg/m2 sc)
• Cardiac Arrhythmia
• Lower limbs occlusive arterial disease
• Impossibility to understand the information form