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Chronic kidney disease(CKD) patients have high incidence of coronary artery problems event after renal transplantation. And remain a major cause of mortality. The major risk marker is arterial stiffness. The cardio-ankle vascular index (CAVI) is a new index of overall stiffness and can estimated the risk of atherosclerosis.
Fibroblast growth factor 21 (FGF-21) is a metabolic regulator that plays important role in cardiac remodeling elevated FGF-21 have been reported in coronary heart disease or carotid artery plaque and could be biomarkers for atherosclerosis disease Investigators aimed to study the association between CAVI and FGF-21 and their relations to various parameters that can contribute to cardiovascular disease eg. homocysteine Echocardiogram findings and other traditional basic factors.
A total of 90 participants who underwent renal transplant were included in the study. The following measures were done and laboratory data were collected. CAVI, Ecchocariogram, Homocysteine, Hs-CRP, Carotid IMT, FGF-21, Medication after renal transplantation, incidence of cardiovascular disease correlation between categorical data was done by using Pearson's correlation test and multiple regression analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CAVI and FGF-21 | renal transplant patients for more than 1 month measured FGF-21 and CAVI |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CAVI and FGF-21 | Other | FGf-21 and CAVI was measured in renal transplant patients group and study correlation with arterial stiffness |
|
| Measure | Description | Time Frame |
|---|---|---|
| association between CAVI and FGF-21 with arterial stiffness in renal transplant patients | cross sectional study | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| association between Hs-CRP,Homocystein with CAVI | cross sectional study | 1 month |
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Inclusion Criteria:
Exclusion Criteria:
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renal transplant pateints for more than 1 month
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| Name | Affiliation | Role |
|---|---|---|
| Thananda Trakarnvanich, M.D. | Bangkok metropolitan administration medical college of vajira hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bangkok metropolitan administraiton of vajira hospital | Bangkok | Bangkok | 10170 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 14581387 | Background | Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, McCullough PA, Kasiske BL, Kelepouris E, Klag MJ, Parfrey P, Pfeffer M, Raij L, Spinosa DJ, Wilson PW; American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation. 2003 Oct 28;108(17):2154-69. doi: 10.1161/01.CIR.0000095676.90936.80. No abstract available. | |
| 22293928 |
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Data about CAVI and FGF 21
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| ID | Term |
|---|---|
| C414620 | fibroblast growth factor 21 |
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| Background |
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